Home > Medicine > Medicine: general issues > Intérêt pronostique de l'anticorps anti-delta-caténine dans les lésions précancéreuses du cancer colo-rectal
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Intérêt pronostique de l'anticorps anti-delta-caténine dans les lésions précancéreuses du cancer colo-rectal

Intérêt pronostique de l'anticorps anti-delta-caténine dans les lésions précancéreuses du cancer colo-rectal

          
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About the Book

Introduction: Le cancer colorectal par sa fréquence et sa gravité représente un problème de santé majeur dans le monde. Il peut se développer à partir de lésions précancéreuses ou adénomes de bas puis de haut grade.La delta-caténine est récemment identifiée comme l'un des facteurs impliqués dans l'initiation, la promotion et la progression du cancer colorectal. Objectifs du travail: Nos objectifs étaient d'évaluer l'expression de la delta-caténine dans les adénomes de bas grade, de haut grade et dans les carcinomes colo-rectaux et d'étudier les facteurs histopronostiques et l'évolution des patients en fonction du taux d'expression de la delta-caténine par immunohistochimie. Matériels et méthodes: L'anticorps anti-delta-caténine est testé, à l'aide de la technique d'immunohistochimie, sur 3 groupes de 7 patients, selectionnés selon le type de la lésion, colligés au sein du service d'Anatomie et Cytologie Pathologique de l'Institut Salah Azaiz sur une période de 16 ans (2002-2018).Résultats: Nos résultats ont montré que le marquage des cellules tumorales et l'intensité du marquage étaient faibles dans les adénomes de bas grade, modérés dans les adénomes de haut grade et plus intenses dans les adénocarcinomes. L'étude des facteurs histopronostiques du cancer colorectal en fonction du niveau d'expression de la delta-caténine montrait que l'immunomarquage était plus intense dans les stades avancés. L'étude de l'évolution des patients révélait aussi que le marquage par la delta-caténine était plus important dans les cas ayant une progression évoluée. Discussion: Selon les données de la littérature, la delta-caténine est absente ou faiblement exprimée dans le cytoplasme de cellules épithéliales colorectales normales contrairement aux cellules tumorales où elle est sur-exprimée. Elle est associée aux facteurs de mauvais pronostic du cancer colorectal. Il est confirmé que sa valeur est plus élevée dans les stades avancés. Ceci est en harmonie avec nos résultats qui ont montré des taux d'expression qui s'élevaient allant de l'adénome de bas grade vers l'adénome de haut grade et de l'adénocarcinome.Conclusion: Ces résultats suggèrent alors, que la surexpression de la delta-caténine pourrait favoriser la transformation maligne des adénomes colo-rectaux, la prolifération des cellules tumorales et leur progression dans la paroi colorectale et au-delà. Des études sur des échantillons plus larges sont souhaitables.


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Product Details
  • ISBN-13: 9786203428322
  • Publisher: Editions Universitaires Europeennes
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 114 gr
  • ISBN-10: 6203428329
  • Publisher Date: 17 Nov 2021
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm


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Intérêt pronostique de l'anticorps anti-delta-caténine dans les lésions précancéreuses du cancer colo-rectal
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