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L-Dopa-Substitution Der Parkinson-Krankheit

L-Dopa-Substitution Der Parkinson-Krankheit

          
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About the Book

Gezielte und konsequente Erforschung grundlegender Mechanis- men der Neurotransmission, Entdeckung der biogenen Amine, Er- kennung und Zuordnung von Verhaltensweisen, klinische Beobach- tungsgabe, das Zusammentreffen kongenialer Partner und Zufallig- keiten kennzeichnen den Durchbruch der Erkenntnis, daR neuro- logischen Erkrankungen biochemische Defekte zugrunde liegen, welche pharmakologisch-therapeutisch kompensiert werden k6nnen. Es ist keine Frage, daR diese "Sternstunde" mit Grundlagenforschern wie Arvid Carlsson und Oleh Hornykiewicz und den Klinikern Walther Birkmayer und Andre Barbeau namentlich zu verkniipfen ist. Sie haben das Tor zur weiten biochemischen, histologischen und phar- makologischen Erforschung des Gehirns endgiiltig auf gestoR en. Die Parkinson-Krankheit, flir welche der kausale Zusammenhang von Pathomorphologie, Dopamindefizit und Dopaminsubstitution durch L-DOPA vor rund 25 Jahren festgestellt wurde, gilt auch heute noch als "Modellerkrankung" zur Erforschung neurologischer und psychiatrischer Verhaltensweisen. Einen entscheidenden Beitrag zur Erforschung der grundlegenden Mechanismen dopaminerger Neuro- nen hat die Entwicldung der "Madopar"-Therapie, welche mit Wal- ther Birkmayer so eng verkniipft ist, gebracht. Er ist auch einer der wenigen, welcher den langen Weg von den ersten Ansatzen dieser Basistherapie bis zu den aktuellen modulierten Therapieformen mit- gegangen ist und mitgestaltet hat. Es war daher naheliegend, daR Hoffmann-La Roche anlaRlich des 75. Geburtstages von Univ. -Prof. Dr. Dr. h. c. Walther Birkmayer zu einem Symposium einlud. Die verschiedenen Facetten des Werde- ganges von Madopar sowie der geschichtliche Riickblick, gepaart mit VI Vorwort personlichen Erlebnissen und Anekdoten, umwoben die wissen- schaftliche Basis dieser Tagung. Die ehrenvoIle Aufgabe, als Editoren des Tagungsberichtes zu fungieren, haben wir steIlvertretend fur aIle Freunde des Jubilars gerne ubernommen.


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Product Details
  • ISBN-13: 9783709188231
  • Publisher: Springer Verlag GmbH
  • Binding: Paperback
  • Height: 229 mm
  • No of Pages: 158
  • Series Title: German
  • Sub Title: Geschichte -- Gegenwart -- Zukunft
  • Width: 152 mm
  • ISBN-10: 3709188237
  • Publisher Date: 10 Jan 2012
  • Edition: Softcover Reprint of the Origi ed.
  • Language: German
  • Returnable: N
  • Spine Width: 10 mm
  • Weight: 250 gr


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