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Natural Resistance to Tumors and Viruses

Natural Resistance to Tumors and Viruses

          
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About the Book

Natural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma- lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon- strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com- mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de- fense in host resistance against both viruses and tumors. It is evi- dent that considerable variation in the relative importance of di- stinct mechanisms may be found among various resistance sy- stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro- priately complex effector mechanisms. Instances, however, whe- re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru- ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media- tor. The present volume provides insight into current concepts of such resistance mechanisms.


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Product Details
  • ISBN-13: 9783642680717
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: Softcover reprint of the original 1st ed. 1981
  • Language: English
  • Returnable: Y
  • Spine Width: 8 mm
  • Width: 170 mm
  • ISBN-10: 3642680712
  • Publisher Date: 09 Jan 2012
  • Binding: Paperback
  • Height: 244 mm
  • No of Pages: 130
  • Series Title: Current Topics in Microbiology and Immmunology
  • Weight: 236 gr


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