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Tumor Bone Diseases and Osteoporosis in Cancer Patients: Pathophysiology: Diagnosis and Therapy

Tumor Bone Diseases and Osteoporosis in Cancer Patients: Pathophysiology: Diagnosis and Therapy

          
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About the Book

With bone metastases found to develop in more than half of patients with advanced cancers, this remarkable reference sheds much-needed light on the relation of various cancers-particularly breast and prostate cancer and multiple myeloma-to bone morbidity. The book addresses new therapies that can reduce the frequency of morbid skeletal events by as much as half. Examines cancer's effects on bone tissue from pathophysiological, diagnostic, monitoring, and therapeutic points of view! Written by more than 40 international experts in the field, Tumor Bone Diseases and Osteoporosis in Cancer Patients reviews the basics of bone physiology investigates the propensity of breast cancer cells to metastasize in bone due primarily to the abundance of growth factors in the skeletal microenvironment-strongly supporting the seed-and-soil hypothesis of the metastatic process discusses the efficacy of local radiotherapy and radioactive isotopes in treating bone metastases covers endocrine and chemotherapy trials on patients with bone metastases explores osteoclast activation and direct osteolytic effects of metastatic cancer cells evaluates the noncytotoxic treatments of bisphosphonates as potent inhibitors of osteoclast-mediated bone resorption assesses bisphosphonates as agents for ameliorating pain and preventing metastases in cancer patients describes preventive therapy against osteoporosis and more! Containing over 1700 references and more than 200 tables, drawings, and micrographs, Tumor Bone Diseases and Osteoporosis in Cancer Patients is a first-rank resource for medical, surgical, and clinical oncologists and radiotherapists, endocrinologists, internists, biologists, biochemists, and graduate and medical school students in these disciplines.

Table of Contents:
Pathophysiology Basic Principles of Bone Physiology Stavros C. Manolagas, Robert S. Weinstein, and Robert L. Jilka Humoral Hypercalcemia of Malignancy: The Discovery of PTHrP Vivian Grill, Wayne Rankin, and T. John Martin Cellular and Molecular Mechanisms of Development of Skeletal Metastases Toshiyuki Yoneda, Paul J. Williams, Akira Myoi, Toshimi Michigami, and Gabriel Mbalaviele Pathogenesis of Osteoblastic Metastases David Goltzman and S. A. Rabbani Clinical Aspects Clinical Aspects of Bone Metastases R. D. Rubens Diagnosis and Monitoring Diagnosis and Monitoring of Bone Metastases: Clinical Means Martin Pecherstorfer and Michael Vesely Diagnosis and Monitoring of Bone Metastases: Scintigraphy Gary J. R. Cook and Ignac Fogelman Radiographic Diagnosis and Monitoring of Bone Metastases Michael Parsa and Mark D. Murphey Diagnosis and Monitoring of Bone Metastases: Tumor Markers John Hilkens and Hans Bonfrer Markers of Bone Turnover in Diagnosis and Monitoring of Bone Metastases Aurelie Fontana, Patrick Garnero, and Pierre D. Delmas Treatment of Bone Metastases: Classical Approach Treatment of Bone Metastases: Chemo- and Hormone Therapy Richard L. Theriault and Gabriel Hortobagyi Treatment of Bone Pain Rachel C. Koshy and Stuart A. Grossman Radiotherapy Peter J. Hoskin Palliation of Painful Bone Metastases: Radioactive Isotopes David F. Preston, Kirman G. Baxter, Margi Schiefelbein, and Jay A. Spicer Orthopedic Management of Skeletal Metastases Cynthia K. Rubert, Robert M. Henshaw, and Martin M. Malawer Treatment of Bone Metastases: Inhibitors of Osteoclastic Bone Resorption Bisphosphonates: Introduction and Mechanisms of Action in Tumor Prevention Herbert A. Fleisch The Clinical Pharmacology of Bisphosphonates R. Graham Russell, Peter J. Croucher, and Michael J. Rogers Treatment of Tumor-Induced Hypercalcemia Stuart H. Ralston Treatment of Tumor-Induced Osteolysis and Prevention of Skeletal-Related Events in Patients with Bone Metastases Robert E. Coleman Prospects of Bisphosphonates for the Prevention of Bone Metastases Alexander H. G. Paterson Bisphosphonates in the Treatment of Multiple Myeloma John A. Kanis and Eugene V. McCloskey Gallium Nitrate and Bone Metastases Raymond P. Warrell, Jr. Osteoporosis in Patients with a History of Breast Cancer: Causes and Diagnosis Brent Winding, Henrik L. Jørgensen, and Claus Christiansen Osteoporosis in Patients with a History of Breast Cancer Treated with Estrogen-Replacement Therapy Kathleen I. Pritchard Osteoporosis in Patients with a History of Breast Cancer: Bisphosphonates and Other Drugs D. Thiébaud and Peter Burckhardt


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Product Details
  • ISBN-13: 9780824763992
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Edition: 1st
  • Language: English
  • Returnable: N
  • Spine Width: 28 mm
  • Weight: 1089 gr
  • ISBN-10: 0824763998
  • Publisher Date: 22 Oct 1999
  • Binding: Hardback
  • Height: 279 mm
  • No of Pages: 584
  • Series Title: English
  • Sub Title: Pathophysiology: Diagnosis and Therapy
  • Width: 216 mm


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