Laishram Rajendrakumar Singh

Prof. Laishram R. Singh is a pioneer in the field of osmolyte research. He has made several landmark contributions in understanding protein folding mechanism by osmolytes and harnessing the basic knowledge in designing strategies for the thrapeutic intervention of human diseases caused by protein folding defects. He obtained his doctoral degree (in the year 2006) from Jamia Millia Islamia, New Delhi from where he begins his research on osmoprotectants, unveiling their role in protein folding landscape and thermodynamics of protein folding. He then expanded his expertise during his postdoctoral studies at Fox Chase Cancer Cancer, Philadelphia by employing these molecules for restoring functions to disease causing mutant proteins related to homocystinuria. Nowadays, metabolomic studies has further expanded the repertoire of osmolytic molecules that are upregulated or downregulated under various disease conditions including neurodegenerative diseases. Presently, at the University of Delhi, he is engaged on identifying specific brain osmolytes that could regulate the functional activity of acetylcholinesterase and carbonic anhydrase (important target enzymes of Dementia). He is also interested in using these osmolytes to correct folding defects of some of the folding deficient brain proteins including, Aβ, α-synuclein, transthyretin whose toxic inclusions are the emblematic signatures of Dementia. He has published more than 85 articles related to the avenue “osmolyte research” in various journals of high international repute. He is a prolific reviewer, guest editors, and is in the editorial board members of prestigious journals.