close menu
Bookswagon-24x7 online bookstore
close menu
My Account
Antibiotics: Part 2 Containing the Beta-Lactam Structure(67 / 2 Handbook of Experimental Pharmacology)

Antibiotics: Part 2 Containing the Beta-Lactam Structure(67 / 2 Handbook of Experimental Pharmacology)

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist

About the Book

Table of Contents:
12 Bacterial Enzymes Interacting with ?-Lactam Antibiotics.- A. Introduction.- I. Classification of ?-Lactam Antibiotics.- II. Mode of Action of ?-Lactam Antibiotics.- 1. Structure and Synthesis of Peptidoglycan.- 2. The Tipper and Strominger Hypothesis for Penicillin Action.- III. Classification of Enzymes Interacting with ?-Lactam Antibiotics.- 1. Enzymes Acting on Peptidoglycan.- 2. Enzymes Degrading ?-Lactam Antibiotics.- B. Bacterial Proteins Binding ?-Lactam Antibiotics.- I. General.- II. Penicillin-Binding Proteins in Gram-Negative Bacteria.- 1. Escherichia coli.- 2. Other Enterobacteria.- 3. Pseudomonads.- 4. Other Bacteria.- III. Penicillin-Binding Proteins in Gram-Positive Bacteria.- 1. Bacilli.- 2. Micrococci.- 3. Streptococci.- 4. Actinomycetes.- C. Enzymes Inhibited by ?-Lactam Antibiotics.- I. dd-Carboxypeptidases.- 1. dd-Carboxypeptidases in Gram-Negative Bacteria.- 2. dd-Carboxypeptidases in Gram-Positive Bacteria.- II. Peptidoglycan Transpeptidase.- D. ?-Lactamases.- I. General.- II. ?-Lactamases in Gram-Positive Bacteria.- 1. Staphylococci.- 2. Bacilli.- 3. Streptomycetes.- 4. Other Actinomycetes.- III. ?-Lactamases in Gram-Negative Bacteria.- 1. Anaerobic.- 2. Aerobic.- E. Interaction with the ?-Lactam Nucleus.- I. Components of the Interaction.- 1. Kinetic Parameters.- 2. Conformational Changes.- 3. Nature of the Covalent Complex.- 4. Nature of Release Products.- II. Streptomyces R61 dd-Carboxypeptidase.- III. ?-Lactamases and ?-Lactam Inhibitors.- 1. Clavulanic Acid.- 2. Penicillin Sulfones.- 3. Halopenicillanic Acids.- 4. Carbapenems.- F. Concluding Remarks.- References.- 13 In Vitro and In Vivo Laboratory Evaluation of ?-Lactam Antibiotics.- A. Historical.- I. Penicillins.- II. Cephalosporins.- III. Cephamycins (7-?-Methoxy Cephalosporins).- IV. ?-Lactams of Novel Structure.- B. ?-Lactam Laboratory Evaluation Procedures.- I. Introduction.- II. In Vitro Test Procedures.- 1. Spectrum of Activity and Sensitivity Tests.- 2. Speed of Action Test.- 3. Susceptibility Disc Test.- 4. Interaction and Synergy Tests.- 5. Effect on Morphology.- 6. Procedures Using Anaerobes.- 7. Factors Influencing In Vitro Tests.- 8. Enzymes and Resistance to ?-Lactam Antibiotics.- 9. Automation and Miniaturization.- 10. In Vitro Models to Simulate In Vivo Conditions.- III. In Vivo Test Procedures.- 1. Mouse Protection Test.- 2. Specialized Test Procedures.- 3. Tests Using Anaerobes.- IV. In Vitro-In Vivo Relationships.- C. Representative ?-Lactam Agents.- References.- 14 ?-Lactam Antibiotics: Structure-Activity Relationships.- A. Introduction: Scope.- I. Structure.- II. Activity.- B. Clinically Useful Penicillins.- I. Natural, Biosynthetic, and Related Penicillins.- II. Penicillinase-Resistant Penicillins.- III. Broad-Spectrum Penicillins.- 1. ?-Aminopenicillins.- 2. ?-Carboxy and ?-Sulfopenicillins.- 3. Acylampicillins.- 4. 6-Acylamino Alternatives: Quaternary Heterocyclic Aminopenicillanic Acids and 6-Amidinopenicillanic Acids.- 5. A 6?-Methoxy Penicillin (Temocillin).- C. Clinically Useful Cephalosporins.- I. Basic Structure-Activity Relationships.- II. ?-Lactamase-Sensitive Cephalosporins.- 1. 7?-Acylamino Group Modifications.- 2. Metabolic Stability.- 3. 3-Substituent Modifications.- III. Cephalosporins with Special Pharmacokinetic Properties.- 1. Cephalosporins with High and Prolonged Serum Levels.- 2. Cephalosporins Absorbed Orally.- IV. ?-Lactamase-Resistant Cephalosporins.- 1. Cephalosporins with Moderate ?-Lactamase Resistance.- 2. Cephamycins.- 3. Cephalosporins with Significant ?-Lactamase Resistance.- V. Oxacephalosporins.- D. Nonclassic ?-Lactams.- I. Penems and Carbapenems.- 1. Carbapenems: Thienamycins, Olivanic Acids, and Related Structures.- 2. Penems.- 3. Oxapenems.- II. Monocyclic ?-Lactams.- 1. Nocardicins.- 2. Monobactams.- III. ?-Lactamase Inhibitors.- 1. Penicillins and Cephalosporins as Inhibitors.- 2. Progressive ?-Lactamase Inhibitors.- E. Other Structure-Activity Relationships.- References.- 15 Pharmacokinetics of ?-Lactam Antibiotics.- A. Introduction.- B. Penicillins.- I. Benzylpenicillin (Penicillin G).- II. Phenoxyalkylpenicillins.- 1. Phenoxymethylpenicillin (Penicillin V).- 2. Pheneticillin.- 3. Propicillin.- 4. Phenbenicillin.- III. Clometocillin.- IV. Methicillin.- V. Ancillin.- VI. Nafcillin.- VII. Isoxazolylpenicillins.- 1. Oxacillin.- 2. Cloxacillin.- 3. Dicloxacillin.- 4. Flucloxacillin.- VIII. Ampicillin.- 1. Hetacillin.- 2. Pivampicillin.- 3. Bacampicillin.- 4. Talampicillin.- 5. Metampicillin.- 6. Methoxymethyl Ester of Hetacillin.- IX. Amoxicillin.- X. Azidocillin.- XI. Epicillin.- XII. Cyclacillin.- XIII. Carbenicillin.- 1. Carindacillin.- 2. Carfecillin.- XIV. Ticarcillin.- XV. Sulbenicillin.- XVI. Ureidopenicillins.- 1. Azlocillin.- 2. Mezlocillin.- 3. Piperacillin.- 4. Bay k 4999.- 5. BL-P1654.- C. Cephalosporins.- I. Cephalosporanic Acids.- 1. Cephalothin.- 2. Cephapirin.- 3. Cefotaxime.- 4. Cephaloglycine.- 5. Cephacetrile.- II. Desacetoxycephalosporanic Acids.- 1. Cephalexin.- 2. Cephradine.- 3. Cefadroxil.- 4. FR-10612.- 5. HR-580.- 6. RMI 19,592.- III. 3-(5-Methyl-1,3,4-thiadiazol-2-ylthiomethyl)ceph-3-em-4-oic Acids.- 1. Cefazolin.- 2. Cephanone.- 3. Cefazedone.- 4. Ceftezole.- IV. 3-(1-Pyridylmethyl)-ceph-3-em-4-oic Acids.- 1. Cephaloridine.- 2. Cefsulodin (CGP 7174/E, SCE-129).- 3. GR20263.- V. 3-{[(1-Methyl-1H-tetrazol-5-yl)thio]methyl}-ceph-3-em-4-oic Acids.- 1. Cefamandole Nafate.- 2. Ceforanide.- 3. Cefazaflur.- 4. Cefoperazone.- 5. Cefonicid (SKF-75073).- VI. Derivatives of 3-Desacetoxymethylcephalosporanic Acid.- 1. Cefroxadine.- 2. Cefaclor.- 3. Cefatrizine.- VII. Cefuroxime.- VIII. Ceftizoxime.- IX. Ro 13-9904.- X. Cephamycins.- 1. Cefoxitin.- 2. Cefmetazole (CS-1170).- D. Other ?-Lactam Antibiotics.- I. Moxalactam (LY 127935).- II. Clavulanic Acid.- III. Mecillinam.- References.- 16 Toxicology of ?-Lactam Antibiotics.- A. Introduction.- B. Local Reactions to Parenteral Administration.- C. Gastrointestinal Side Effects.- I. Nonspecific Diarrhea.- II. Pseudomembranous Colitis.- III. Ischemic Colitis.- D. Immunologically Mediated Toxicity.- I. Human Toxicity.- II. Sensitization Process.- E Immune Hemolytic Anemia.- F. Neutropenia.- G. Disorders of Hemostasis.- I. Thrombesthenia.- II. Plasma Factor Coagulopathy.- III. Thrombocytopenia.- H. Interstitial Nephritis and Cystitis.- I. Clinical Picture.- II Immunofluorescence.- III. Cystitis.- I. Nephrotoxicity.- I. Human Toxicity.- II. Cellular Mechanisms.- 1. Uptake.- 2. Efflux: Cephaloridine.- 3. Reactivity or Receptor Affinity: Cephaloglycin.- III. Less Toxic Cephalosporins.- 1. Additive Aminoglycoside-Cephalosporin Toxicity.- 2. Effects of Ureteral Obstruction.- IV. Molecular Basis of Toxicity.- 1. Metabolite Hypothesis.- 2. Mitochondrial Respiratory Toxicity.- J. Hepatic Toxicity.- K. Neurotoxicity.- I. Human Toxicity.- II. Animal Toxicity.- III. Mechanism.- 1. Effects on Gamma-Aminobutyric Acid (GABA)-Mediated Transmission.- 2. Effects on Chloride Conductance.- 3. Effects on the Sodium-Potassium Exchange Pump.- IV. Structure-Activity Relationships.- V. Regulation of Penicillin Concentration in the Central Nervous System.- VI. Nonspecific Neurotoxic Reactions.- L. Disulfiram-Like Reactions.- M. Newer ?-Lactams.- References.- 17 Therapeutic Application of ?-Lactam Antibiotics.- A. Introduction.- B. Penicillins in the Therapy of Human Infections.- I. The Penams: The Biosynthetic or Natural Penicillins.- 1. Penicillin G (Benzylpenicillin).- 2. Penicillin V and the Acid-Stable Phenoxypenicillins.- II. The Penicillinase-Resistant Penicillins.- 1. Methicillin.- 2. Nafcillin.- 3. Isoxazolyl Penicillins.- III. The Broad-Spectrum Aminopenicillins.- 1. Ampicillin.- 2. Esters of Ampicillin.- 3. Amoxicillin.- 4. Epicillin and Cyclacillin.- IV. The Antipseudomonal Penicillins.- 1. Carbenicillin.- 2. Ticarcillin.- V. The Amidinopenicillanic Acids - Amdinocillin.- VI. The Atypical ?-Lactams.- 1. The Monocyclic ?-Lactams.- 2. The Oxapenams.- 3. The Carbapenems.- 4. The Penems.- C. Cephalosporins in the Therapy of Human Infections.- I. Cephalothin.- II. Cephaloridine.- III. Cefazolin.- IV. Cefamandole.- V. Cefoxitin.- VI. Cefmetazole.- VII. Cefuroxime.- VIII. Ceforanide.- IX. Cefonicid.- X. Third-Generation Cephalosporins.- 1. Cefotaxime.- 2. Ceftizoxime.- 3. Moxalactam.- 4. Cefoperazone.- 5. Ceftriaxon.- 6. Cefmenoxime.- 7. Ceftazidime.- 8. Cefotiam.- 9. Cefsulodin.- XI. The Oral Cephalosporins.- 1. Cephalexin.- 2. Cephradine.- 3. Cefatrizine.- 4. Cefaclor.- 5. Cefroxadine, Cefadroxil, and Cephaloglycin.- D. Antibacterial Chemoprophylaxis with the ?-Lactam Antiobiotics.- I. Prophylactic Uses in Medicine.- II. Prophylactic Uses in Surgery.- E. Use of ?-Lactam Antibiotics in Dental Medicine.- F. Use of ?-Lactam Antibiotics in Veterinary Practice.- References.


Best Seller

| | See All

Product Details
  • ISBN-13: 9783540121312
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Publisher Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Language: English
  • Returnable: N
  • Spine Width: 0 mm
  • Weight: 1115 gr
  • ISBN-10: 3540121315
  • Publisher Date: 01 Jul 1983
  • Binding: Hardback
  • No of Pages: 479
  • Series Title: 67 / 2 Handbook of Experimental Pharmacology
  • Sub Title: Part 2 Containing the Beta-Lactam Structure


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Be The First to Review
Antibiotics: Part 2 Containing the Beta-Lactam Structure(67 / 2 Handbook of Experimental Pharmacology)
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG -
Antibiotics: Part 2 Containing the Beta-Lactam Structure(67 / 2 Handbook of Experimental Pharmacology)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Antibiotics: Part 2 Containing the Beta-Lactam Structure(67 / 2 Handbook of Experimental Pharmacology)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals

    | | See All


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA