These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Table of Contents:
List of Contributors ix Volume 1 1 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1 Humberto De Vitto, Juan P. Valencia, and James A. Radosevich 2 Mitochondria in Focus: Targeting the Cell-Death Mechanism 13 Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna 3 Microbial Programmed Cell Death 49 Neal D. Hammer 4 Autophagy 71 Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi 5 Cell Injury, Adaptation, and Necrosis 83 Sarah G. Fitzpatrick and Sara C. Gordon 6 Necroptosis 99 Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al-Obeidi, Akshay A. D’Cruz, and Motti Gerlic 7 Ferroptosis 127 Ebru Esin Yoruker and Ugur Gezer 8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 145 Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon 9 Cornification 183 Leopold Eckhart 10 Excitotoxicity 197 Julie Alagha, Sulaiman Alshaar, and Zane Deliu 11 Molecular Mechanisms Regulating Wallerian Degeneration 205 Mohammad Tauseef and Madeeha Aqil 12 Pyronecrosis 225 Maryam Khalili and James A. Radosevich 13 Phenoptosis: Programmed Death of an Organism 237 M.V. Skulachev and V.P. Skulachev 14 Molecular Mechanisms Underlying Oxytosis 289 Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee 15 Pyroptosis 317 Kate E. Lawlor, Stephanie Conos, and James E. Vince 16 Paraptosis 343 Maryam Khalili and James A. Radosevich 17 Hematopoiesis and Eryptosis 367 Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. Feldman Volume 2 18 Cyclophilin D-Dependent Necrosis 375 Jatin Mehta and Chandi Charan Mandal 19 Role of Phospholipases in Cell Death 395 Manikanda Raja, Juel Chowdhury, and James A. Radosevich 20 TRIAD (Transcriptional Repression-Induced Atypical Death) 411 Takuya Tamura and Hitoshi Okazawa 21 Alkylating-Agent Cytotoxicity Associated with O6-Methylguanine 427 Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley 22 Entosis 463 Jamuna A. Bai and Ravishankar Rai V. 23 Mitotic Catastrophe 475 Raquel De Souza, Lais Costa Ayub, and Kenneth Yip 24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Benefits and Costs 511 Marko Radic 25 Parthanatos: Poly ADP Ribose Polymerase (PARP)-Mediated Cell Death 535 Amos Fatokun 26 Methuosis: Drinking to Death 559 Madeeha Aqil 27 Oncosis 567 Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja 28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583 J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers 29 Programmed Death 1 (PD1)-Mediated T-Cell Apoptosis and Cancer Immunotherapy 695 Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati