About the Book
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 34. Chapters: Penicillin, Ampicillin, Beta-lactamase, Amoxicillin, Beta-lactam antibiotic, New Delhi metallo-beta-lactamase, History of penicillin, Flucloxacillin, Co-amoxiclav, Dicloxacillin, Mecillinam, Temocillin, Pivmecillinam, Nafcillin, Phenoxymethylpenicillin, Meticillin, Benzylpenicillin, Piperacillin, Pivampicillin, Ciclacillin, Mezlocillin, Ticarcillin, Procaine benzylpenicillin, Carbenicillin, Co-fluampicil, Ampicillin/sulbactam, Benzylpenicilloyl polylysine, Penimepicycline, Sultamicillin, Benzathine benzylpenicillin, Carindacillin, Hetacillin, Azlocillin, Synulox, Bacampicillin, Metampicillin, Sulbenicillin, Epicillin, Carfecillin, Tigemonam, Benzathine phenoxymethylpenicillin, Penamecillin, Nocardicin A, Monobactam, Clometocillin, Azidocillin, Carboxypenicillin, Talampicillin, Carumonam, Ureidopenicillin, Aminopenicillin, Pheneticillin, Propicillin, Antistaphylococcal penicillins, Cephem. Excerpt: Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephamycins, and carbapenems (ertapenem). (Cephalosporins are relatively resistant to beta-lactamase.) These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of Gram-positive and Gram-negative bacteria. Beta-lactamases produced by Gram-negative organisms are usually secreted. The structure of a Streptomyces lactamase is given by 1BSG. Penicillinase is a specific type of -lactamase, showing specificity for penicillins, again by hydrolysing the beta-lactam ring. Molecular weights of the various penicillinases tend to cluster near 50kiloDalton. Penicilli...
