Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; and medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine.

Table of Contents:
Part I: 1. Embryonic stem cells Nicole Slawny and Gary D. Smith; 2. Induced pluripotent stem cells Akitsu Hotta and Shinya Yamanaka; 3. Connective tissue stem and progenitor cells Pamela Gehron Robey; 4. Hematopoietic stem cells and their niches Geeta Mehta, Yusuke Shiozawa and Russell Taichman; 5. Using biomaterials for stem cell isolation, expansion and directed-differentiation David Mack, Aleksander Skardal, Shay Soker and Anthony Atala; 6. The hematopoietic stem cell niche Aparna Venkatraman, Meng Zhao and Linheng Li; Part II: 7. Nanofibrous polymer scaffolds with designed pore structure for regeneration Zhanpeng Zhang, Jeremy M. Holzwarth and Peter X. Ma; 8. Electrospun micro/nano-fibrous scaffolds Vince Beachley and Xuejun Wen; 9. Biologic scaffolds for regenerative medicine Vineet Agrawal and Stephen F. Badylak; 10. Bioceramic scaffolds Youliang Hong, Zhanwen Xiao, Bangcheng Yang and Xingdong Zhang; 11. Collagen based tissue repair composite Xiaoming Li and Fu-zhai Cui; 12. Polymer/ceramic composite scaffolds for tissue regeneration Ian O. Smith, Melanie J. Gupte and Peter X. Ma; 13. Computer aided tissue engineering for modeling and fabrication of three-dimensional tissue scaffolds Qudus Hamid, Chengyang Wang, Jessica Snyder and Wei Sun; Part III: 14. Polysaccharide hydrogels for regenerative medicine applications Jacob A. Simson and Jennifer H. Elisseeff; 15. Functionalized poly(ethylene glycol) hydrogels for controlling stem cell fate Chien-Chi Lin; 16. Fumarate-based hydrogels in regenerative medicine applications Steven Lu, Kyobum Kim, Johnny Lam, F. Kurtis Kasper and Antonios G. Mikos; 17. Hydrogel scaffolds for regenerative medicine E. A. Sander, E. D. Grassl and R. T. Tranquillo; 18. Microfabricated gels for tissue engineering Gulden Camci-Unal, Jesper Hjortnaes, Hojae Bae, Mehmet Remzi Dokmeci and Ali Khademhosseini; 19. Organ printing Tao Xu, Daniel Reyna-Soriano, Jorge I. Rodríguez-Dévora, Mohammod Bhuyan and Thomas Boland; Part IV: 20. Growth factor delivery on scaffolds Kai Feng, Jiang Hu, Zubad Newaz and Peter X. Ma; 21. Gene delivery for periodontal regeneration A. D. Taut and W. V. Giannobile; 22. Endogenous stem/progenitor cell recruitment for tissue regeneration Mildred Embree, Chang Hun Lee, Ziming Dong, Mo Chen, Kimi Kong, Hemin Nie, Avital Mendelson, Bhranti Shah, Shoko Cho, Takahiro Suzuki, Rujing Yang, Nan Jiang and Jeremy J. Mao; 23. Affinity-based delivery systems Jeffrey Mark Halpern and Horst A. von Recum; 24. DNA delivery for regeneration Stephanie K. Seidlits, Kelan Hlavaty and Lonnie D. Shea; Part V: 25. Bone regeneration Eric Hsu, Pedro Alvarez, Lyndsey Schutte, Amy Donovan, Singuang Liu, Arun R. Shivats and Jeffrey O. Hollinger; 26. Biomaterials for engineered tendon regeneration Wei Liu and Yilin Cao; 27. Advancing articular cartilage repair through tissue engineering from materials and cells to clinical translation Megan J. Farrell and Robert L. Mauck; 28. Engineering tissue-to-tissue interfaces Nora T. Khanarian, Nancy M. Lee, Marissa R. Solomon and Helen H. Lu; 29. Models of composite bone and soft tissue limb trauma Brent A. Uhrig, Mon-Tzu A. Li, Nick J. Willett and Robert E. Guldberg; 30. Mesenchymal stem cells Weibo Zhang and Pamela C. Yelick; 31. Dentin-pulp tissue engineering and regeneration Jing Wang, Xiaobing Jin and Peter X. Ma; 32. Dental enamel regeneration Xanthippi Chatzistavrou and Petros Papagerakis; 33. Hair follicle and skin regeneration Mayumi Ito and Makoto Takeo; 34. In vitro blood vessel regeneration Sashka Dimitrievska and Laura E. Niklason; 35. Stem cells for vascular engineering Y. Eugene Chen, Changqing Xie and Bo Yang; 36. Cardiac tissue regeneration in bioreactors Loraine L. Y. Chiu, Boyang Zhang, Yun Xiao and Milica Radisic; 37. Bladder regeneration Yuanyuan Zhang and Anthony Atala.