The book discusses in a detailed manner various nanomaterials used for biomedical applications, including clinical applications, diagnosis and tissue engineering. After the presentation of an overview of biomedical nanomaterials, including their classification and applications, the first part of the book is devoted to biomedical nanomaterials for therapy applications. For example, polymer micelles, dendrimers, polymer-drug conjugates as well as antibody-drug conjugates are discussed with respect to their cancer drug delivery properties. The next parts discuss biomedical nanomaterials that are used for imaging, diagnosis and sensors, as well as for tissue engineering. In the final section, the safety of biomedical nanomaterials is elaborated.

Table of Contents:
List of Contributors XV 1 Pharmacokinetics and Pharmacodynamics (PK/PD) of Bionanomaterials 1 Ergang Liu, Meng Zhang, and Yongzhuo Huang 1.1 Introduction 1 1.2 Commonly Utilized NMs in Pharmaceutical Research 2 1.3 In vivo Biodistribution and the Evolving Targeting Principles for NMs 6 1.4 Processing NMs by the Biological Systems 9 1.5 Rational Design of Long-Circulating NMs 13 1.6 Mathematic Simulation of NM-Mediated Cancer Drug Delivery 15 1.7 Experimental PK Data of the Applied NMs 25 1.8 Perspectives 50 References 50 2 Targeted Dendrimers for Cancer Diagnosis and Therapy 61 Jingjing Hu, Ke Hu, and Yiyun Cheng 2.1 Introduction 61 2.2 Targeted Dendrimers for Cancer Therapy 63 2.3 Targeted Dendrimers for Cancer Diagnosis 73 2.4 Conclusions 77 References 78 3 Polymeric Micelles for Drug Delivery 87 Wei Wu and Xiqun Jiang 3.1 Introduction 87 3.2 Amphiphilic Copolymers for Micelle Preparation 88 3.3 Stability of Polymeric Micelles 91 3.4 Drug Incorporation of Polymeric Micelles 92 3.5 Functionalization of Polymeric Micelles 93 3.6 Conclusions 93 References 94 4 Polymeric Micelle-Based Nanomedicine 99 Bin He 4.1 Introduction to Chemotherapy 99 4.2 Polymeric Micelle-Based Nanomedicine 100 4.3 Perspective 109 References 110 5 Microfluidics Applications in Cancer Drug Delivery 117 Hao Zhang and Youqing Shen 5.1 Introduction 117 5.2 Basic Principles of Micellar Drug Carriers and Microfluidics 118 5.3 Microfluidic Fabrication of Polymer Micelles 121 5.4 On-Chip Characterization of Micelle Formation 128 5.5 Microfluidic Replications of Physiological Barriers During Delivery of Drug to Tumor 133 5.6 Conclusion and Implications for Future Research 141 Acknowledgment 141 References 142 6 Antibody–Drug Conjugates 149 Xinyu Liu andWeiping Gao 6.1 Introduction 149 6.2 History of ADCs 151 6.3 Components of ADCs 155 6.4 Future Directions 167 References 170 7 Nano-Photosensitizer for Imaging-Guided Tumor Phototherapy 177 Zonghai Sheng,Mingbin Zheng, and Lintao Cai 7.1 Introduction for Tumor Phototherapy 177 7.2 Functionalized Nano-Photosensitizer for Tumor Targeting 178 7.3 Nano-photosensitizer for Photodynamic Therapy 182 7.4 Nano-Photosensitizer for PhotothermalTherapy 184 7.5 Nano-Photosensitizer for Combination Therapy 191 7.6 Perspective and Application 197 References 200 8 Quantum Dots for Cancer Diagnosis 207 Min Fang, Dai-Wen Pang, and Yan Li 8.1 Introduction 207 8.2 Detection of Solid Tumor Based on QDs 209 8.3 SLN Mapping 215 8.4 Detection of Tumor-Associated Proteins in Blood 216 8.5 Detection of CTCs 217 8.6 Tumor Microenvironment for Invasion and Metastasis 217 8.7 Challenges of QDs into Clinical Practice Application 220 8.8 Summary 221 References 221 9 Luminescent Gold Nanoclusters for Biomedical Diagnosis 227 Hui Jiang and Xuemei Wang 9.1 Gold Nanostructures in Biomedical Diagnosis 227 9.2 Luminescent Au NCs for Biosensing 227 9.3 Au NCs for Cell Imaging 231 9.4 Au NCs for In Vivo Imaging 241 9.5 Perspectives 245 References 247 10 Nanographene in Biomedical Applications 251 Kai Yang and Zhuang Liu 10.1 Introduction 251 10.2 Nanographene for Drug Delivery 251 10.3 Nanographene for Gene Delivery 253 10.4 Graphene-Based Nanocomposite for Drug Delivery 255 10.5 Nanographene for Phototherapies of Cancer 259 10.6 Graphene and its Nanocomposites for Biomedical Imaging and Imaging-GuidedTherapy 263 10.7 Toxicity of Nanographene 268 10.8 Prospects and Challenges 276 References 278 11 Molecular Imprinting Technique for Biomimetic Sensing and Diagnostics 283 Huiqi Zhang, Man Zhao, and Yaqiong Yang 11.1 Introduction 283 11.2 Molecularly Imprinted Polymers (MIPs) 283 11.3 MIPs for Biomimetic Sensing and Diagnostics 286 11.4 Conclusions and Outlook 309 Acknowledgments 311 References 311 12 Magnetic Nanostructures for MRI-Based Cancer Detection 327 Yanglong Hou and Jing Yu 12.1 Introduction 327 12.2 Chemical Synthesis of Magnetic Nanostructures 328 12.3 Magnetic Nanostructures for MRI-Based Cancer Detection 344 12.4 Conclusions and Perspective 354 Acknowledgments 355 References 355 13 Magnetic Iron Oxide Nanoparticles: Bioapplications and Potential Toxicity 361 Hongying Su, Yun Zeng, Chengchao Chu, and Gang Liu 13.1 Introduction 361 13.2 Bioapplications of Magnetic Iron Oxide Nanoparticles 362 13.3 Potential Toxicity of Magnetic Iron Oxide Nanoparticles 369 13.4 Surface Engineering for Bioapplications 377 13.5 Conclusion 379 Acknowledgments 379 References 379 14 Nanostructured Hydrogels for Diabetic Management 387 Ying Guan and Yongjun Zhang 14.1 Introduction 387 14.2 Nanostructured Hydrogels for Insulin Releasing 388 14.3 Nanostructured Hydrogels for Glucose Sensing 396 14.4 Nanostructured Hydrogels in Artificial Pancreas 403 14.5 Conclusions and Outlook 411 References 412 15 Inorganic Nanomaterials for Bone Tissue Engineering 421 Yongxiang Luo, Chengtie Wu, and Jiang Chang 15.1 Introduction 421 15.2 Calcium Phosphate Nanomaterials for Bone Tissue Engineering 422 15.3 CaP Blocks and Scaffolds with Surface Nanostructure 427 15.4 Mesoporous Bioactive Glasses for Bone Tissue Engineering 430 15.5 Conclusions 431 Acknowledgments 432 References 432 16 Nanotechnology in Coronary Artery Stent Coating 437 Tao Liu and Junying Chen 16.1 Introduction 437 16.2 Biodegradable Polymer Coating 438 16.3 Nanocomposite Stent Coating 440 16.4 Nanostructure in Stent Coating 443 16.5 Bioactive Nanocoating 449 16.6 Summary and Future Outlook 453 References 455 Index 465