close menu
Bookswagon-24x7 online bookstore
close menu
My Account
Home > Medicine & Health Science textbooks > Medicine: general issues > Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)
21%
Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)

Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)

          
5
4
3
2
1

Available


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Quantity:
Add to Wishlist
X

About the Book

This book records the proceedings of a joint U.S.-Japan symposium on the chem­ istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona­ tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ................... , 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.

Table of Contents:
Contentst.- Status Reports.- Summary of the Bleomycin Symposium.- Advances in Bleomycin Studies.- Review of the Structural Studies on Bleomycin.- Synthetic and Biosynthetic Studies.- Studies on the Total Synthesis of Bleomycin.- A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.- Biogenetic Aspects of Bleomycin-Phleomycin Group Antibiotics.- Physical and Spectral Analysis of Bleomycin.- Liquid Chromatography of Bleomycin.- NMR Study of Bleomycin.- Bleomycin as a Metal Chelator.- 1H-NMR Study of the Metal Binding Sites of Bleomycin.- The Metallobleomycins.- Metal Complex of Bleomycinand Its Implication for the Mechanism of Bleomycin Action.- Electron Spin Resonance Studies of 1: 1:1 Bleomycin-Cobalt(II)-Oxygen Adduct Complex.- Interaction of Bleomycin with DNA.- A Role for Iron in the Degradation of DNA.- Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNAby Bleomycin.- Interaction of Bleomycinwith DNA.- A Molecular Basis for the Interaction of Bleomycin with DNA.- Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNA.- The Use of Covalently Closed Circular DNA to Investigate Properties of Bleomycin and Its Analogs.- The Action of Bleomycin on DNA.- Biological Effects of Bleomycin.- Polyamines and the Toxicity of the Bleomycins.- Cytotoxicity of the Various Bleomycins to Cultured Mammalian Cells.- Upward-Concave Dose-Response Relationship in Bleomycin Lethality of Mammalian Cells.- Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine.- Bleomycin-Induced Pulmonary Toxicity: A Model for the Study of Pulmonary Fibrosis.- Concluding Remarks at the Symposium on Bleomycin.- Practical Methods for the Manipulation and Assay of Bleomycin.- A Practical Method for the Separation ofBleomycin Components.- Preparation of Bleomycinic Acid from Bleomycin A2.- A Practical Method for Preparing Copper-Free Bleomycin A2.- A Simple Assay for Bleomycin Activity: Degradation of Radioactive DNA to Acid-Soluble Products.


Best Sellers


Product Details
  • ISBN-13: 9781461261933
  • Publisher: Springer-Verlag New York Inc.
  • Publisher Imprint: Springer-Verlag New York Inc.
  • Edition: Softcover reprint of the original 1st ed. 1979
  • Language: English
  • Returnable: N
  • Series Title: English
  • Sub Title: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978
  • Width: 155 mm
  • ISBN-10: 1461261937
  • Publisher Date: 12 Oct 2011
  • Binding: Paperback
  • Height: 235 mm
  • No of Pages: 351
  • Returnable: Y
  • Spine Width: 19 mm
  • Weight: 516 gr


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)
Springer-Verlag New York Inc. -
Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978(English)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA