About the Book
Part I Overview
1. Updates on Cardiac Gene Therapy Research and Methods: Overview of Cardiac Gene Therapy
Francisco J. Romeo, Spyros A. Marvopoulos, and Kiyotake Ishikawa
Part II Gene Suppression, Editing, and Reprogramming
2. Tough Decoy-Mediated Cardiac Gene Suppression
Changwon Kho
3. Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes using miRcombo
Camilla Paoletti, Carla Divieto, and Valeria Chiono
4. CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC Derived Cardiomyocytes to Probe Ca2+ Signaling Aberrancies of CPVT Arrhythmogenesis
Naohiro Yamaguchi, Xiao-Hua Zhang, and Martin Morad
5. Enhancing Cardiomyocyte Transcription using In Vivo CRISPR/Cas9 Systems
Eric Schoger and Laura C. Zelarayán
6. AAV Mediated Somatic Gene Editing for Cardiac and Skeletal Muscle in a Large Animal Model
Tilman Ziegler, Tarik Bozoglu, and Christian Kupatt
Part III Cardiac Gene Therapy Vectors and Promotors
7. Optimization of Synthesis of Modified mRNA
Jimeen Yoo and Lior Zangi
8. Design and Production of Heart Chamber-Specific AAV9 Vectors
Alina S. Bilal, Donna J. Thuerauf, Erik A. Blackwood, and
Christopher C. Glembotski
9. Generation of Atrial-Specific Construct using Sarcolipin Promoter Associated CRM4 Enhancer
Dongtak Jeong
Part IV Cardiac Gene Delivery Methods
10. Cardiac Targeted Adeno-Associated Virus Injection in Rats
Michael G. Katz, Yoav Hadas, Adam S. Vincek, Nataly Shtraizent, Eric Schadt, and Efrat Eliyahu
11. Cardiac Gene Delivery in Large Animal Models-Antegrade Techniques
Spyros A. Mavropoulos, Kelly P. Yamada, Tomoki Sakata, and Kiyotake Ishikawa
12. Locked Nucleic Acid AntimiR Therapy for the Heart
Sabine Samolovac and Rabea Hinkel
13. Cardiac Gene Delivery in Large Animal Models: Selective Retrograde Venous Injection
Philipp Schlegel and Philip W. J. Raake
14. Endocardial Gene Delivery using NOGA Catheter System
Satu Siimes, Niko Järveläinen, Henna Korpela, and Seppo Ylä-Herttuala
15. Surgical Methods for Cardiac Gene Delivery in Large Animals
Michael G. Katz, Yoav Hadas, Adam S. Vincek, Nataly Shtraizent, Hylton P. Gordon, Peter Pastuszko, Eric Schadt, and Efrat Eliyahu
16. Atrial Gene Painting in Large Animal Model of Atrial Fibrillation
Weilan Mo and J. Kevin Donahue
17. Stent-Based Gene Delivery for Coronary Disease
Ivan S. Alferiev, Michael Chorny, Robert L. Wilensky, Robert J. Levy, and Ilia Fishbein
18. Selective Anti-AAV Antibody Depletion by Hemapheresis and Immunoadsorption
Alejandro Orlowski and Thomas Weber
19. Ex Vivo Delivery of Viral Vectors by Organ Perfusion for Cardiac Transplantation Gene Therapy
Michelle Mendiola Pla, Amy Evans, Paul Lezberg, and Dawn E. Bowles
Part V Pulmonary Hypertension
20. Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models
Malik Bisserier, Olivier Boucherat, Sebastien Bonnet, and Lahouaria Hadri
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