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Coexpresion de Egfr/Her2 En El Cancer Local Avanzado de Cervix.

Coexpresion de Egfr/Her2 En El Cancer Local Avanzado de Cervix.

          
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About the Book

El objetivo principal de nuestro trabajo fue determinar el impacto de la co-expresión de los receptores de factor de crecimiento epidérmico EGFR y Her2 en la supervivencia libre de enfermedad (SLE) y en la supervivencia libre de fracaso pélvico (SLFP) en pacientes con cáncer de cérvix local avanzado (CCLA) tratadas con quimioradioterapia concurrente. La expresión de EGFR y Her2 fue evaluada mediante técnicas inmunohistoquímicas de manera centralizada. Se estudiaron biopsias de 170 pacientes con CCLA tratadas con quimioradioterapia concurrente de las cuales 25(15%) fueron considerados EGFR y Her2 positivo, 100(59%) eran EGFR o Her2 positivos, y 45 (26%) fueron EGFR y Her2 negativos. La SLE a 3 y 5 años fue del 39% y 39% para las pacientes EGFR y Her2 positivo, del 54% y 49% para las EGFR o Her2 positivo, y del 76% y 72%, respectivamente, para las EGFR y Her2 negativos (p = 0,006). Los tumores EGFR y Her2 positivos se asociaron significativamente a una disminución en la SLFP (HR, 3,99; IC 95%, 1,44 - 11, p = 0,007) y SLE (HR 2.9, IC 95%, 1.26-6.66, p = 0,01). Las pacientes con CCLA que coexpresaron EGFR y Her2 tuvieron un peor pronóstico en cuanto a una menor SLE y SLFP.


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Product Details
  • ISBN-13: 9783847355908
  • Publisher: Eae Editorial Academia Espanola
  • Publisher Imprint: Eae Editorial Academia Espanola
  • Height: 229 mm
  • No of Pages: 112
  • Series Title: Spanish
  • Weight: 177 gr
  • ISBN-10: 3847355902
  • Publisher Date: 10 Jun 2012
  • Binding: Paperback
  • Language: Spanish
  • Returnable: N
  • Spine Width: 7 mm
  • Width: 152 mm


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