Leading researchers in the life sciences and engineers involved in research of transport phenomena in biological systems have contributed chapters that identify, analyze, and modify the control and regulation mechanisms of transport phenomena in biological systems, with particular emphasis on the cardiac system.

Included in the contributions to this volume are the following topics: signaling mechanisms and transport phenomena; blood-tissue exchange and inter-tissue transport; cellular membrane transport and endocytosis of ions and metabolites; intracellular transport, energetics, and molecular motors; system biology, uni- and multi-scale transport models, and hierarchical analysis; and clinical considerations -- cardiac protection, metabolic and pharmaceutical augmentation, and interferences.

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Part I: Signaling Pathways and Transport Phenomena:.

1. The Death of Transcriptional Chauvinism in the Control and Regulation of Cardiac Contractility: Sakthivel Sadayappan and Jeffrey Robbins.

2. Genetic Mechanisms Controlling Cardiovascular Development: Jamie Bentham and Shoumo Bhattacharya.

3. MicroRNAs Control Gene Expression: Importance for Cardiac Development and Pathophysiology: Daniele Catalucci, Michael V.G. Latronico and Gianluigi Condorelli.

4. Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair: Developmental Role of Periostin: Russell A. Norris, Thomas K. Borg, Jonathan T. Butcher and Roger R. Markwald.

Part II: Intra-cellular Transport and Energetics:.

5. The Missing Link in the Mystery of Normal Automaticity of Cardiac Pacemaker Cells: Edward G. Lakatta, Tatiana M. Vinogradova, and Victor A. Maltsev.

6. Shear Fluid Induced Ca2+ Release and the Role of Mitochondria in Rat Cardiac Myocytes: Steve Belmonte and Martin Morad.

7. Cardiac Cell Hypertrophy in vitro: Role of Calcineurin/NFAT as Ca2+ Signal Integrators: Matilde Colella and Tullio Pozzan.

8. The Role of Ca2+ in Coupling Cardiac Metabolism with Regulation of Contraction. in Silico Model: Yael Yaniv, William C. Stanley, Gerald M. Saidel, Marco Cabrera, and Amir Landesberg.

9. Sarcomere Mechanics in Uniform and Nonuniform Cardiac Muscle: Henk E.D.J. Ter Keurs, Tsuyoshi Shinozaki, Ying Ming Zhang, Yuji Wakayama,Yoshinao Sugai, Yutaka Kagaya, Masahito Miura, Penelope A Boyden, Bruno D.M. Stuyvers, and Amir Landesberg.

Part III: Ions and Metabolites Membrane Transport:.

10. Modulation of Cardiac Performance by Motor Protein Gene Transfer: Todd J. Herron Eric J. Devaney and Joseph M. Metzger.

11. Atrial-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation: Alexander Burashnikov, José M. Di Diego, Andrew C. Zygmunt, Luiz Belardinelli, and Charles Antzelevitch.

12. Molecular Basis of Cardiac Action Potential Repolarization: Yoram Rudy.

13. Intracellular Transport: From Physics to … Biology: Aurélien Roux, Damien Cuvelier, Patricia Bassereau and Bruno Goud.

Part IV: Inter-tissue Transport:.

14. Linking Cellular Energetics to Local Flow Regulation in the Heart: James B. Bassingthwaighte.

15. Regulation of Endothelial Junctional Permeability: Emily Vandenbroucke, Dolly Mehta, Richard Minshall and Asrar B. Malik.

16. Controlling Cardiac Transport and Plaque Formation: Ze'ev Aronis, Sagi Raz, Elisha J.P. Martinez, and Shmuel Einav.

Part V: Transport Models and Hierarchical Analysis:.

17. Multiscale and Modular Analysis of Cardiac Energy Metabolism: Repairing the Broken Interfaces of Isolated System Components: Johannes H.G.M. van Beek.

18. Discovering Regulators of the Drosophila Cardiac Hypoxia Response using Automated Phenotyping Technology: Jacob D. Feala, Jeffrey H. Omens, Giovanni Paternostro, Andrew D. McCulloch.

19. Multi-scale Model of 02 Transport and Metabolism: Response to Exercise: Haiying Zhou, Nicola Lai, Gerald M. Saidel and Marco Cabrera.

Part VI: Clinical Aspects:.

20. Mapping Preconditioning’s Signaling Pathways: An Engineering Approach: James M. Downey, Thomas Krieg and Michael V. Cohen.

21. The Identity and Regulation of the Mitochondrial Permeability Transition Pore: Where the Known Meets the Unknown: Magdalena Juhaszova, Su Wang, Dmitry B. Zorov, H. Bradley Nuss, Marc Gleichmann, Mark P. Mattson and Steven J. Sollott.

22. Control of Cardiac Rate by “Funny” Channels in Health and Disease: Andrea Barbuti and Dario DiFrancesco.

23. Experimental Molecular and Stem Cells Therapies in Cardiac Electrophysiology: Lior Gepstein.

24. Controlling Ischemic Cardiovascular Disease: From Basic Mechanisms to Clinical Management: Rafael Beyar