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Data Mining in Structural Biology: Signal Transduction and Beyond(v. 34 Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements)

Data Mining in Structural Biology: Signal Transduction and Beyond(v. 34 Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements)

          
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About the Book

This work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed.

Table of Contents:
C.-H. Heldin: Regulation of Kinases by Growth Factors; E.A. Nigg: Cell Cycle Regulation by Protein Kinases and Phosphatases; L. Johnson: Structural Basis of Substrate Recognition and Control by Protein Kinases; A. Levitzki: The Selectivity of Small Molecules Towards Protein Tyrosine Kinases; H.H. Grunicke et al.: Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C; U. Heinemann: The Berlin "Protein Structure Factory" Initiative: A Technology-Based Approach to Structural Genomics; F.K. Winkler et al.: Structure-Based Approaches in Modern Drug Discovery Research; C.W. Muller: DNA Recognition by NFkB and STAT Transcription Factors; J.-M. Wurtz, D. Moras: Molecular Determinants for Agonists and Antagonist Binding to Steroid Nuclear Receptors; J.D. Norris et al.: Estrogen Receptor-Cofactor Interactions as Target for Novel Drug Discovery.


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Product Details
  • ISBN-13: 9783540414940
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Publisher Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Height: 230 mm
  • No of Pages: 205
  • Series Title: v. 34 Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements
  • Sub Title: Signal Transduction and Beyond
  • Width: mm
  • ISBN-10: 3540414940
  • Publisher Date: 15 May 2001
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Spine Width: mm
  • Weight: 500 gr


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