Diagnostic Pathology: Cardiovascular

Table of Contents:
SECTION 1: HEART, ENDOMYOCARDIAL BIOPSY CONGENITAL/GENETIC 4 Endocardial Fibroelastosis Syndrome Monica P. Revelo, MD, PhD 6 Arrhythmogenic Cardiomyopathy Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Monica P. Revelo, MD, PhD 12 Fatty Acid Metabolic Disorders Monica P. Revelo, MD, PhD 14 Mitochondrial Myopathies Monica P. Revelo, MD, PhD 18 Muscular Dystrophies Monica P. Revelo, MD, PhD 22 Glycogen Storage Diseases Monica P. Revelo, MD, PhD 24 Fabry Disease, Heart Monica P. Revelo, MD, PhD 28 LAMP2 Mutation (Danon Disease) Jagdish Butany, MBBS, MS, FRCPC, Amar Ibrahim, MB, ChB, MSc, and Monica P. Revelo, MD, PhD ACQUIRED 30 Amyloid Deposition, Heart Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD 38 Hemochromatosis, Heart Philippe Romeo, MD and Monica P. Revelo, MD, PhD 40 Anthracycline Cardiotoxicity Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD 42 Catecholamine Cardiomyopathy Monica P. Revelo, MD, PhD 44 Cocaine Cardiotoxicity Dylan V. Miller, MD and Brian J. Hall, MD 46 Immune Checkpoint Inhibitor Toxicity Monica P. Revelo, MD, PhD and Dylan V. Miller, MD INFLAMMATORY 50 Lymphocytic Myocarditis Monica P. Revelo, MD, PhD 54 Giant Cell Myocarditis Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD 56 Eosinophilic (Löffler) Myocarditis Monica P. Revelo, MD, PhD 60 Sarcoidosis, Heart Monica P. Revelo, MD, PhD 62 Acute Rheumatic Carditis Monica P. Revelo, MD, PhD 66 Eosinophilic Granulomatosis With Polyangiitis Monica P. Revelo, MD, PhD 68 Viral Myocarditis Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath 70 Toxoplasmosis, Heart Monica P. Revelo, MD, PhD 72 Chagas Disease, Heart Dylan V. Miller, MD and Brian J. Hall, MD 76 Lyme Disease and Rickettsial Myocarditis Dylan V. Miller, MD and Brian J. Hall, MD 80 SARS-CoV-2 (COVID-19)-Related Cardiovascular Disease Dylan V. Miller, MD and Monica P. Revelo, MD, PhD 84 Lupus Erythematosus, Heart Monica P. Revelo, MD, PhD TRANSPLANT REJECTION 90 Acute Cellular Transplant Rejection, Heart Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD 96 Antibody-Mediated Transplant Rejection, Heart Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD 102 Quilty Lesions Billie Fyfe, MD and Monica P. Revelo, MD, PhD 106 Previous Biopsy Sites, Heart Transplant Billie Fyfe, MD and Monica P. Revelo, MD, PhD 108 Posttransplant Lymphoproliferative Disorder, Heart Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath 110 Harvesting Injury/Acute Ischemia, Heart Billie Fyfe, MD and Monica P. Revelo, MD, PhD SECTION 2: HEART, RESECTION HEART EXPLANT 116 Hypertrophic Cardiomyopathy Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD 122 Idiopathic Dilated Cardiomyopathy Dylan V. Miller, MD 126 Ischemic Heart Disease Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD 130 Overview of Coronary Artery Stents Dylan V. Miller, MD 134 Cardiac Allograft Vasculopathy Monica P. Revelo, MD, PhD 140 Radiation Injury, Heart Dylan V. Miller, MD and Philippe Romeo, MD 142 Cardiac Conduction System Disease Dylan V. Miller, MD 150 Ventricular Assist Devices Dylan V. Miller, MD 156 Approach to Cardiomyopathy (Worksheet) Dylan V. Miller, MD 158 Approach to Cardiomyopathy Diagnosis Dylan V. Miller, MD SECTION 3: HEART, TUMORS BENIGN 166 Cardiac Myxoma Dylan V. Miller, MD and Joseph J. Maleszewski, MD 172 Papillary Fibroelastoma Dylan V. Miller, MD and Joseph J. Maleszewski, MD 176 Cardiac Rhabdomyoma Dylan V. Miller, MD and Joseph J. Maleszewski, MD 180 Cardiac Fibroma Dylan V. Miller, MD and Joseph J. Maleszewski, MD 184 Ectopic Tissues, Heart Dylan V. Miller, MD and Joseph J. Maleszewski, MD 186 Lipomatous Hypertrophy of Atrial Septum Dylan V. Miller, MD and Billie Fyfe, MD MALIGNANT 188 Cardiac Lymphoma Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath 190 Cardiac Angiosarcoma Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD 194 Cardiac Sarcoma, Other Dylan V. Miller, MD and Joseph J. Maleszewski, MD 198 Cardiac Metastases Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC SECTION 4: CARDIAC VALVES, NATIVE AORTIC 206 Unicommissural Aortic Valve Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC 210 Bicuspid Aortic Valve Jagdish Butany, MBBS, MS, FRCPC, Amar Ibrahim, MB, ChB, MSc, and Monica P. Revelo, MD, PhD 214 Senile Calcific Aortic Stenosis Monica P. Revelo, MD, PhD 218 Discrete Membranous Subaortic Stenosis Dylan V. Miller, MD MITRAL 220 Myxomatous Mitral Valve Disease Dylan V. Miller, MD and Philippe Romeo, MD 224 Rheumatic Heart Disease Dylan V. Miller, MD and Philippe Romeo, MD TRICUSPID 228 Carcinoid Heart Disease Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD 232 Ebstein Anomaly Dylan V. Miller, MD and Philippe Romeo, MD PULMONARY 234 Congenital Pulmonary Stenosis Dylan V. Miller, MD and Brian J. Hall, MD ENDOCARDITIS 236 Endocarditis, Native Valve Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD 240 Nonbacterial Thrombotic Endocarditis Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD SECTION 5: CARDIAC VALVES PROSTHETIC 246 Leaflet Degeneration, Prosthetic Valves Jagdish Butany, MBBS, MS, FRCPC and Monica P. Revelo, MD, PhD 250 Thrombosis of Prosthetic Valves Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Amar Ibrahim, MB, ChB, MSc 252 Endocarditis, Prosthetic Valve Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC 258 Mechanical Heart Valve Prostheses: Modes of Failure Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Amar Ibrahim, MB, ChB, MSc 260 Catheter-Deployed Valve Therapies Dylan V. Miller, MD and Monica P. Revelo, MD, PhD SECTION 6: PERICARDIUM INFLAMMATORY 268 Acute Pericarditis Monica P. Revelo, MD, PhD 272 Constrictive Pericarditis Monica P. Revelo, MD, PhD 274 Tuberculous Pericarditis Monica P. Revelo, MD, PhD TUMORS 276 Lymphoma, Pericardium Dylan V. Miller, MD 278 Metastatic Tumor, Pericardium Billie Fyfe, MD and Monica P. Revelo, MD, PhD 282 Mesothelioma, Pericardium Dylan V. Miller, MD and Joseph J. Maleszewski, MD 286 Mesothelial/Monocytic Incidental Cardiac Excrescence Dylan V. Miller, MD SECTION 7: VASCULAR DISEASE ENDARTERECTOMY/ATHERECTOMY/THROMBECTOMY 290 Overview of Peripheral Vascular Specimens Dylan V. Miller, MD and Billie Fyfe, MD 296 Thromboembolus, Vascular Billie Fyfe, MD and Monica P. Revelo, MD, PhD THORACIC AORTA 300 Aortic Degenerative Diseases Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 308 Genetic Diseases of the Aorta Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD 312 Noninfectious Aortitis Dylan V. Miller, MD 316 Takayasu Arteritis Dylan V. Miller, MD 320 Aortic Dissection Dylan V. Miller, MD and Billie Fyfe, MD 324 Aortic Coarctation Dylan V. Miller, MD and Monica P. Revelo, MD, PhD ABDOMINAL AORTA 328 Aortic Atherosclerosis and Complications Billie Fyfe, MD and Monica P. Revelo, MD, PhD 334 Chronic Periaortitis and IgG4-Related Disease Dylan V. Miller, MD 336 Mycotic Aneurysm Monica P. Revelo, MD, PhD CORONARY ARTERIES 340 Atherosclerosis, Coronary Monica P. Revelo, MD, PhD 344 Coronary Artery Dissection Monica P. Revelo, MD, PhD 348 Kawasaki Disease Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD 352 Coronary Artery Emboli Monica P. Revelo, MD, PhD TEMPORAL ARTERIES 354 Giant Cell/Temporal Arteritis Dylan V. Miller, MD and Monica P. Revelo, MD, PhD PERIPHERAL VESSELS 358 Buerger Disease (Thromboangiitis Obliterans) Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC 362 Fibromuscular Dysplasia Dylan V. Miller, MD and A. Brad Farris, III, MD 368 Segmental Arterial Mediolysis Dylan V. Miller, MD 370 Mönckeberg Medial Calcific Sclerosis Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD 372 Behçet Disease Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 376 Infectious Vasculitis Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 382 Lymphocytic Venulitis Monica P. Revelo, MD, PhD 384 Varicosities Dylan V. Miller, MD and Billie Fyfe, MD 386 Hypertensive Renovascular Diseases Dylan V. Miller, MD, A. Brad Farris, III, MD, and Brandon T. Larsen, MD, PhD VASCULAR TISSUE GRAFTS 390 Vascular Graft Pseudoaneurysm Jagdish Butany, MBBS, MS, FRCPC, Pooja Gupta, MBBS, DNB, and Monica P. Revelo, MD, PhD SECTION 8: VASCULAR TUMORS BENIGN 396 Hemangioma Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 406 Angiomyolipoma Dylan V. Miller, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD 410 Glomus Tumor Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 418 Cystic Lymphangioma Monica P. Revelo, MD, PhD 420 Arteriovenous Malformations Dylan V. Miller, MD MALIGNANT 424 Epithelioid Hemangioendothelioma Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 428 Kaposi Sarcoma Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 434 Angiosarcoma Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD SECTION 9: AUTOPSY CARDIAC 442 Coronary Artery Bypass Grafting Dylan V. Miller, MD 446 Valve Replacement (Including Transcatheter) Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 452 Infective Endocarditis Dylan V. Miller, MD 458 Ventricular Assist Device Insertion Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD 462 Heart Transplant Dylan V. Miller, MD VASCULAR 468 Thoracic Aortic Aneurysm Repair Dylan V. Miller, MD, Billie Fyfe, MD, and George P. Batsides, MD 474 Abdominal Aortic Aneurysm Dylan V. Miller, MD and Billie Fyfe, MD 478 Cerebral Aneurysm and Vascular Malformation Dylan V. Miller, MD and Roy H. Rhodes, MD, PhD