This two-volume set provides a full account of the entire sequence of drug development, from conceptualizing the drug, creating a library of candidates, and conducting clinical trials, to optimizing the synthetic route, marketing the drug, and developing delivery methods. Comprehensive in scope, the set bridges the gap between medicinal and process chemistry. Discussion includes the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Case studies examine the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Full chapters are devoted to combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics. Industrial chemists, biologists, biochemists, and business people in the pharmaceutical industry will all benefit from this authoritative reference. The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary. The second volume describes optimizing the synthetic route; manufacturing, outsourcing, and marketing the drug, including coloring; and developing delivery methods.

Table of Contents:
Bioactive Molecules in Medicinal Plants: A Perspective on their Therapeutic Action / S C Taneja, G N Qazi Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools / Steven V Ley, Ian R Baxendale, Deborah A Longbottom, Rebecca M Myers Insulin Sensitizers: Emerging Therapeutics / Braj B Lohray, Vidya B Lohray Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals / Raymond McCague, Ian C Lennon Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons / J S Yadav, S Chandrasekhar Carbohydrates: From Chirons to Mimics / G V M Sharma, Palakodety Radha Krishna Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients / Yatendra Kumar, B Vijayaraghavan Importance of Polymorphs and Salts in the Pharmaceutical Industry / Bipin Pandey, Vidya B Lohray, Braj B Lohray Role of Outsourcing in Drug Manufacture / Peter Pollak Regulation-Driven Process Chemistry / Shrikant V Kulkarni Chemical Process Scale-Up Tools: Mixing Calculations, Statistical Design of Experiments, and Automated Laboratory Reactors / Andrei A Zlota Library Quality Metrics / Richard L Wife, Johan Tijhuis Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine / Mukund S Chorghade, Mahendra N Deshpande, Richard J Pariza Building Contract Research Businesses Based on Integration of Basic and Applied Research / Mukund S Chorghade, Mukund K Gurjar, C V Ramana, Sreenivas Punna Principles and Practice of Clinical Drug Development / Colin Scott Index. Volume 1. Drug discovery [chapters 1-16] Volume 2. Drug development [chapters 17-31]. From patent to prescription : paving the perilous path to profit / Richard J. Pariza Medicinal chemistry in the new millennium : a glance into the future / Paul W. Erhardt Contemporary drug discovery / Lester A. Mitscher, Apurba Dutta Combinatorial chemistry in the drug discovery process / Ian Hughes Parallel solution-phase synthesis / Norton P. Peet, Hwa-Ok Kim Timing of analog research in medicinal chemistry / János Fischer, Anikó Gere Possible alternatives to high-throughput screening / Camille G. Wermuth Proteomics and drug discovery / Susan Dana Jones, Peter G. Warren Using drug metabolism databases during drug design and development / Paul W. Erhardt Discovery of the antiulcer drug Tagamet / C. Robin Ganellin Discovery of potent nonpeptide vasopressin receptor antagonists / Bruce E. Maryanoff Discovery and development of the ultrashort-acting analgesic Remifentanil / Paul L. Feldman Discovery and development of Nevirapine / Karl Grozinger, John Proudfoot, Karl Hargrave Applications of nuclear imaging in drug discovery and development / John W. Babich, William C. Eckelman Polymeric sequestrants as nonabsorbed human therapeutics / Pradeep K. Dhal, Chad C. Huval, S. Randall Holmes-Farley Botanical immunomodulators and chemoprotectants in cancer therapy / Bhushan Patwardhan, Manish Gautam, Sham Diwanay Bioactive molecules in medicinal plants : a perspective on their therapeutic action / S.C. Taneja, G.N. Qazi Natural products as an inspiration for the discovery of new high-throughput chemical synthesis tools / Steven V. Ley, Ian R. Baxendale, Deborah A. Longbottom, Rebecca M. Myers Insulin sensitizers : emerging therapeutics / Braj B. Lohray, Vidya B. Lohray Criteria for industrial readiness of chiral catalysis technology for the synthesis of pharmaceuticals / Raymond McCague, Ian C. Lennon Enantioselective synthesis of propargyl alcohols as multifunctional synthons / J.S. Yadav, S. Chandrasekhar Carbohydrates : from chirons to mimics / G.V.M. Sharma, Palakodety Radha Krishna Meeting the challenges of process development and scale-up of active pharmaceutical ingredients / Yatendra Kumar, B. Vijayaraghavan Importance of polymorphs and salts in the pharmaceutical industry / Bipin Pandey, Vidya B. Lohray, Braj B. Lohray Role of outsourcing in drug manufacture / Peter Pollak Regulation-driven process chemistry / Shrikant V. Kulkarni Chemical process scale-up tools : mixing calculations, statistical design of experiments, and automated laboratory reactors / Andrei A. Zlota Library quality metrics / Richard L. Wife, Johan Tijhuis Tying a GABA from Copenhagen to Chicago : the chemistry of Tiagabine / Mukund S. Chorghade, Mahendra N. Deshpande, Richard J. Pariza Building contract research businesses based on integration of basic and applied research / Mukund S. Chorghade, Mukund K. Gurjar, C.V. Ramana, Sreenivas Punna Principles and practice of clinical drug development / Colin Scott