Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pharmacology > Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)
46%
Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)

Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)

          
5
4
3
2
1

Available


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Quantity:
Add to Wishlist

About the Book

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits.

Table of Contents:
Part I. Tools 1. Designing a Diverse High Quality Library for Crystallography Based FBDD Screening Brett A. Tounge, Michael H. Parker 2. Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies Thomas B. Acton, Rong Xiao, James Aramini, William A. Buchwald, Colleen Ciccosanti, Ken Conover, Keith Hamilton, Yuanpeng Janet Huang, Haleema Janjua, Paolo Rossi, Seema Sharma, G.V.T.Swapna, Huang Wang, Li Zhao, Gaetano T. Montelione 3. Key Factors for Successful Generation of Protein-Fragment Structures: Requirements on Protein, Crystals, and Technology Anja Jestel, Stefan Steinbacher 4. Automated Crystal Amplification and Compound Dispensation for FBDD Analysis Francis A. Lewandowski, Brett A. Tounge, Cynthia M. Milligan 5. Hardware and Protocols for Rapid Fragment Based Structure Determination Richard S. Alexander, John C. Spurlino 6. Using Computational Techniques in Fragment-Based Drug Discovery Renee L. DesJarlais 7. Computational Approaches to De Novo Discovery of Fragment Binding for Unprecedented Protein States Zenon D. Konteatis, Jinming Zou, Anthony E. Klon, Siavash Meshkat Part II. Practical Approaches 8. How to Avoid Rediscovering the Known Lawrence C. Kuo 9. From Experimental Design to Data Analysis: A Comprehensive Walk-Through of Fragment Identification Using Surface Plasmon Resonance Anthony M. Giannetti 10. Practical Aspects of NMR Based Fragment Screening Christopher Lepre 11. Fluorescent Protein Thermal Shifts to Identify Low Molecular Weight Fragments James K. Kranz, Matthew J. Todd 12. A HTS Reporter Displacement Assay for Fragment Screening and Fragment Evolution Towards Leads with Optimized Binding Affinity, Binding Kinetics, and Kinetic Selectivity Lars Neumann 13. Fragment Screening of Stabilized G-Protein Coupled Receptors Using Biophysical Methods Miles Congreve, Fiona H. Marshall, David Myszka, Gregg Siegal 14. Predicting the Success of a Fragment Screening by X-Ray Crystallography Douglas Davies, Lance Stewart 15. Fragment Screening Purely with Protein Crystallography John C. Spurlino 16. Structure Density Relationship Based FBDD Marta C. Abad, Xuqing Zhang, Alan C. Gibbs Part III. Lead Generation Examples 17. Lead Generation and Examples – Opinions Regarding How to Follow Up Hits Masaya Orita, Kazuki Ohno, Masaichi Warizaya, Yasushi Amano, Tatsuya Niimi 18. High Throughput Thermodynamics for Selection of Fragment Hits and Guidance of Fragment Evolution Lars Neumann 19. Medicinal Chemistry Inspired Fragment Based Drug Discovery James C. Lanter, Xuqing Zhang, Zhihua Sui 20. Experiences in Fragment-Based Lead Discovery Roderick E. Hubbard, James B. Murray 21. Advancing Fragment Binders to Lead Like Compounds Using Ligand and Protein Based NMR Spectroscopy Till Maurer 22. Effective Progression of NMR-Directed Fragment Hits Hugh Eaton, Daniel Wyss 23. Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment Douglas Davies, Lance Stewart


Best Sellers


Product Details
  • ISBN-13: 9780123812742
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Depth: 38
  • Height: 229 mm
  • No of Pages: 645
  • Series Title: Volume 493 Methods in Enzymology
  • Sub Title: Volume 493 Tools, Practical Approaches, and Examples
  • Weight: 1190 gr
  • ISBN-10: 0123812747
  • Publisher Date: 21 Apr 2011
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 36 mm
  • Volume: 493
  • Width: 152 mm


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)
Elsevier Science Publishing Co Inc -
Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Fragment Based Drug Design: Volume 493 Tools, Practical Approaches, and Examples(Volume 493 Methods in Enzymology)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA