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Functions of the Natural Immune System

Functions of the Natural Immune System

          
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About the Book

Twenty contributions examine a variety of functions reportedly mediated by cells within the natural immune system and review the diverse functional activities of the lymphoid cells. Major emphasis is on the reactivity of natural effector cells specifically within the lymphoid populations. Annotation

Table of Contents:
I. Role of the Natural Immune System in the Control of Tumor Cell Growth.- 1 Role of the Natural Immune System in Control of Primary Tumors and Metastasis.- 1. Introduction.- 2. Role of NK Cells in Host Resistance to Primary-Tumor Growth.- 3. NK Cells and Metastatic Growth.- 4. Role of NK Cells in the Antimetastatic Effects of Anticoagulant Drugs.- 5. Major Histocompatibility Complex (MHC) Antigen Expression and NK Sensitivity of Tumor Cells.- 6. Role in Immune Surveillance against Tumors.- 7. Stimulation of Natural Cell-Mediated Immunity and Treatment of Tumor Metastases.- References.- 2 Lymphokine-Activated Killer Cells: Biology and Therapeutic Efficacy.- 1. Introduction.- 2. Characterization and in Vitro Activity of Murine Lymphokine-Activated Killer Cells.- 3. Adoptive Immunotherapy in Murine Tumor Models.- 4. Mechanisms of Adoptive Immunotherapy and Toxicity in the Murine Model.- 5. Characterization of Human Lymphokine-Activated Killer Cells.- 6. Clinical Trials of Lymphokine-Activated Killer Cells and IL-2 in the Therapy of Metastatic Cancer.- 7. Future Prospects and Conclusions.- References.- Summary of Part I.- II. Involvement of the NIS in the Control of Microbial Iinfections.- 3 Natural Effector Cells in Influenza Virus Infection.- 1. Historical Perspective of NK Cells and Influenza Infection.- 2. Interferon and Influenza Infection.- 3. Role of NK Cells during Influenza Virus Infection.- 4. Pathological Consequences of NK Activity.- 5. Conclusions.- References.- 4 Natural Host Defense Systems Active against Herpes Simplex Virus Infections.- 1. Introduction.- 2. Mouse Studies.- 3. Human Studies.- 4. Conclusions.- References.- 5 Factors Influencing the Control of Virus Infections by Natural Killer Cells.- 1. Introduction.- 2. NK-Resistant and NK-Sensitive Viruses.- 3. Age-Dependent Resistance.- 4. Site of Virus Replication.- 5. Interferon-Mediated Effects on Target Cells.- 6. Mechanisms of Selective Lysis of Virus-Infected Target Cells by NK Cells.- 7. Use of NK Cells to Treat Virus Infections.- References.- 6 Natural Killer Cell-Mediated Resistance to Animal Parasites.- 1. Introduction.- 2. Interactions between Natural Killer Cells and Parasites.- 3. Parasites and Antibody-Facilitated Killer Cells.- 4. Conclusions.- References.- 7 Natural Host Resistance Mechanisms against Systemic Mycotic Agents.- 1. Introduction.- 2. Role of Monocytes/Macrophages in Host Defense.- 3. Role of Polymorphonuclear Leukocytes in Host Defense.- 4. Natural Killer Cells and Other Nonphagocytic Effector Cells in Host Defense.- 5. Summary.- References.- 8 Role of Natural Killer Cells in Inflammation and Antibacterial Activity.- 1. Introduction.- 2. Locomotion of Large Granular Lymphocytes.- 3. In Vivo Migratory Responses for Large Granular Lymphocytes/NK Cells.- 4. Can NK Cells Regulate the Inflammatory Response?.- 5. Do NK Cells Have Antibacterial Activity?.- 6. Concluding Remarks.- References.- Summary of Part II.- III. Immunoregulatory Properties of the NIS.- 9 Role of the Natural Immune System in the Antibody Response: Regulatory Effect of NK Cells.- 1. Introduction.- 2. B Cell Differentiation and Antibody Response.- 3. Evidence for Regulation of Antibody Response by NK Cells.- 4. Cellular Interaction in NK Regulation of B Cell Differentiation and Ig Secretion.- 5. Production of Cytokines by NK Cells and Their Role in the Regulation of Antibody Response.- 6. Conclusions and Summary.- References.- 10 Role of Natural Effector Cells in the Regulation of Cell-Mediated Immune Responses.- 1. Introduction.- 2. Characteristics of Natural Immunoregulatory Effector Cells.- 3. Regulation of Cell-Mediated Immune Functions.- 4. Relevance to Disease States.- 5. Summary and Future Directions.- References.- 11 Control of Hematopoietic Progenitor Cells by Natural Killer Cells.- 1. Introduction.- 2. Experimental and Clinical in Vivo Evidence for a Role of NK Cells in Regulation of Hematopoiesis.- 3. Inhibition of in Vitro Hematopoiesis by Human NK Cells.- 4. Role of Soluble Factors in the Modulation of Hematopoiesis by Lymphocytes.- 5. Regulation of the Production of Cytotoxins by Human Lymphocytes.- 6. Conclusions.- References.- 12 Characterization and Functions of the Natural Suppressor Cell Systems.- 1. NS Cell Systems: Where They Are Found.- 2. NS Cells: Development and Mode of Action.- 3. In Vivo Relevance of NS Cell Activity.- 4. Potential Therapeutic Use of NS Cell Activity.- 5. Directions of Future Research.- References.- 13 Cytokine Production by CD3- Large Granular Lymphocytes.- 1. Introduction.- 2. Interferon Production.- 3. Interleukin Production.- 4. Cytotoxic and Cytostatic Factors.- 5. Production of Factors by Cloned LGL.- 6. Cell Phenotype and Stimuli.- 7. Conclusion and Remarks.- References.- Summary of Part III.- IV. Involvement of the NIS in Bone Marrow and Allograft Rejection.- 14 Involvement of Natural Effector Cells in Bone Marrow Transplantation and Hybrid Resistance.- 1. Introduction.- 2. Genetic Control of the Target Structure.- 3. NK Cell Involvement in Hemopoietic Resistance.- References.- 15 Natural Cytotoxicity and Allograft Rejection.- 1. Identification of the Natural Killer Cells.- 2. Changes in Systemic NK Activity after Transplantation and during Rejection.- 3. Changes in Local NK Activity inside the Rejecting Allograft.- 4. Possible Functions of NK Cells and LGL in Acute Allograft Rejection.- 5. Summary and Conclusions.- References.- Summary of Part IV.- V. Involvement of the NIS in Various Pathological Conditions.- 16 Involvement of Natural Effector Cells in Graft versus Host Disease.- 1. Introduction.- 2. Evidence against a Role of NE Cells in Initiating GVHD.- 3. Evidence for a role of NE Cells in Initiating GVHD.- 4. Relationship of IL-2 and IL-2 Receptor-Bearing Cells on NE Cells and GVHD Progression.- 5. Conclusions.- References.- 17 The Natural Immune System and Hematocytopenias.- 1. Introduction.- 2. Cellular Immunity and Severe Aplastic Anemia.- 3. Cellular Immunity and Pure Red Cell Aplasia.- 4. Cellular Immunity and Neutropenia.- 5. Cellular Immunity and Thrombocytopenia.- 6. LGL Proliferative Disorders and Hematocytopenias.- 7. Critique of Investigation Methods.- 8. Perspective on the Investigation of Immune-Mediated Cytopenia.- References.- 18 The Natural Immune System in Autoimmune and Neurological Disease.- 1. Introduction.- 2. Abnormalities in the Immune Response Leading to Depressed NK Activity.- 3. Systemic Lupus Erythematosus and Sjögren’s Syndrome.- 4. Rheumatoid Arthritis.- 5. Hashimoto’s Thyroiditis and Graves’ Disease.- 6. Relationship of the Natural Immune Response to the Central Nervous System.- 7. Multiple Sclerosis and Other Neurological Diseases.- 8. Conclusions.- References.- 19 Natural Killer Cells and Diabetes Mellitus.- 1. Introduction.- 2. Type I Diabetes Mellitus.- 3. Animal Models.- 4. Mechanisms of Islet Damage.- 5. The Future.- References.- 20 Role of Natural Effector Cells in Human Gastrointestinal Disease.- 1. Introduction.- 2. Cytotoxic Lymphocytes in the Human Intestine.- 3. Intestinal Macrophages.- 4. Intestinal Mast Cells.- 5. Role of Cytotoxic Lymphocytes in Liver Disease.- References.- Summary of Part V.


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Product Details
  • ISBN-13: 9780306429514
  • Publisher: Springer Science+Business Media
  • Publisher Imprint: Kluwer Academic/Plenum Publishers
  • Edition: 1989 ed.
  • No of Pages: 485
  • Series Title: English
  • ISBN-10: 0306429519
  • Publisher Date: 31 Jan 1989
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Weight: 870 gr


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