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G Protein-Coupled Receptor Kinases

G Protein-Coupled Receptor Kinases



About the Book

Part I: Introduction

1. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery

Vsevolod V. Gurevich and Eugenia V. Gurevich

Part II: GRK Structure, Mechanisms of Activation, and Interaction with GPCRs

2. Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7

Tivadar Orban and Krzysztof Palczewski

3. Visual G Protein-Coupled Receptor Kinases

Chih-Chun Hsu and Ching-Kang Jason Chen

4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily

Tyler S. Beyett, Sumit J. Bandekar, and John J.G. Tesmer

5. "Barcode" and Differential Effects of GPCR Phosphorylation by Different GRKs

Kunhong Xiao and Hongda Liu

Part III: GRKs in Cell Signaling

6. Cell-Type Specific GRK2 Interactomes: Physiopathological Implications

Federico Mayor, Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas, Clara Reglero, Petronila Penela, and Cristina Murga

7. Differential Regulation of IGF-1 and Insulin Signaling by GRKs

Leonard Girnita, Ada Girnita, and Caitrin Crudden

8. Differential Control of Potassium Channel Activity by GRK2

Adi Raveh, Liora Guy-David, and Eitan Reuveny

Part IV: Physiological and Pathophysiological Mechanisms Regulated by GRKs

9. Critical Role of GRK2 in the Prevention of Chronic Pain

Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, and Annemieke Kavelaars

10. Roles of GRK Dysfunction in Alzheimer's Pathogenesis

William Z. Suo

11. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases

Eugenia V. Gurevich, Raul R. Gainetdinov, and Vsevolod V. Gurevich

12. G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation

Alessandro Cannavo, Claudio de Lucia, and Walter J. Koch

13. GRK Roles in C. elegans

Jordan F. Wood and Denise M. Ferkey

14. Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway

Dominic Maier and David R. Hipfner

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Product Details
  • ISBN-13: 9781493937967
  • Publisher: Humana Press
  • Publisher Imprint: Humana Press
  • Edition: 1st ed. 2016
  • Language: English
  • Returnable: Y
  • Spine Width: 21 mm
  • Width: 178 mm
  • ISBN-10: 1493937960
  • Publisher Date: 21 Jul 2016
  • Binding: Hardback
  • Height: 254 mm
  • No of Pages: 329
  • Series Title: Methods in Pharmacology and Toxicology
  • Weight: 815 gr

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