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Genetic Breakthroughs-- Their Implications for You and Your Health (Collection)

Genetic Breakthroughs-- Their Implications for You and Your Health (Collection)

          
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About the Book

3 cutting-edge books reveal the latest genetic breakthroughs – and their implications for you, your health, and your world   These three cutting-edge books reveal how modern genetics has already transformed the world – and will transform it again and again in the coming years. Mobile DNA book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Renowned geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances have opened up new questions, and how new tools and capabilities have encouraged still more progress. He introduces today’s key strategies for advancing the field, and previews long-term research strategies that may lead to even deeper insights. Next, in Investigating the Human Genome, leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases linked to genetics. You’ll discover how these advances are shedding new light on issues ranging from human origins to psychiatric disease, Alzheimer’s to epigenetics. Finally, in Genes, Chromosomes, and Disease, Nicholas Wright Gillham offers an exceptionally readable overview of the rise and transformations of medical genetics – and of the eugenic impulses that it has inspired.   From world-renowned leaders and experts, including Haig H. Kazazian, Moyra Smith, and Nicholas Wright Gillham

Table of Contents:
Mobile DNA: Finding Treasure in Junk Preface: Thoughts on Doing Science     xii Chapter 1  Introduction to Mobile DNA     1 Chapter 2  Varieties of Mobile DNA     5 Chapter 3  DNA Transposons     19 Chapter 4  Mobile DNA of Model Organisms     29 Chapter 5  Exceptional Scientists Working on Mobile DNA in Lower Organisms     35 Chapter 6  Role of Bioinformatics in Genome Analysis     43 Chapter 7  The Prologue     49 Chapter 8  “Welcome to the Wonderful World of LINEs”     59 Chapter 9  An Experimental Breakthrough     73 Chapter 10  Reverse Transcriptase to the Rescue     81 Chapter 11  A Quirk of L1 Elements–A Lousy 3’ End Is Important for Genome Evolution     85 Chapter 12  A Tour de Force from Tom Eickbush     89 Chapter 13  “I don’t believe all those colonies represent retrotransposition events.”     93 Chapter 14  L1 Encodes an Endonuclease     101 Chapter 15  The Jocks     105 Chapter 16  The Mayor and the Frenchman     115 Chapter 17  Ostertag’s Coups     121 Chapter 18  The Independent Canadian     133 Chapter 19  The Musician Scientist     141 Chapter 20  Young Ladies in the Back Bay     145 Chapter 21  The Brilliant Young Lady from China     157 Chapter 22  Hiroki’s Big Surprises     163 Chapter 23  A Young Man with a Purpose     173 Chapter 24  Other Mobile DNA in Mammalian Genomes     179 Chapter 25  Effects of Retrotransposons on Mammalian Genomes     187 Chapter 26  Host Factors Involved in L1 Retrotransposition     201 Chapter 27  Why Mobile DNA?     207 Chapter 28  The Future of Mobile DNA Research     209 Chapter 29  Predictions for Mobile DNA     221 References     225 Glossary     249 Index     255   Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility Preface     vii Chapter 1  Genome Architecture and Sequence Variation in Health and Disease     1 Chapter 2  Genes and Transcripts: Insight into Regulation at Different Levels     23 Chapter 3  Epigenetics: Modifications of DNA, Chromatin, and Gene Expression     37 Chapter 4  Gene Environment Interactions     53 Chapter 5  Pathways, Phenotypes, and Phenocopies     67 Chapter 6  Dynamic Function, Synaptic Activity, and Plasticity     81 Chapter 7  Late Onset Neurodegenerative Diseases     101 Chapter 8  Genes and Genomes in Cancer: Targeted Therapies     131 Chapter 9  Functional Genomics: Personalized Medicine and Therapeutics     153 Epilogue     167 References     171 About the Author     203 Index     205   Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine Preface     ix Chapter 1: Hunting for disease genes     1 Chapter 2: How genetic diseases arise     25 Chapter 3: Ethnicity and genetic disease     55 Chapter 4: Susceptibility genes and risk factors     81 Chapter 5: Genes and cancer     103 Chapter 6: Genes and behavior     129 Chapter 7: Genes and IQ: an unfinished story     151 Chapter 8: Preventing genetic disease     175 Chapter 9: Treating genetic disease     199 Chapter 10: The dawn of personalized medicine     235 Postscript: a cautionary note     249 References and notes     253 Glossary     293 Some useful human genetics Web sites     307 Acknowledgments     309 About the author     311 Index     313  


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Product Details
  • ISBN-13: 9780133039634
  • Publisher: Pearson Education (US)
  • Publisher Imprint: Addison Wesley
  • Language: English
  • ISBN-10: 0133039633
  • Publisher Date: 27 Feb 2012
  • Binding: SA
  • Weight: 1 gr


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