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Genetic and Environmental Determinants of Bone Mineral Density in Southern Chinese: (English)

Genetic and Environmental Determinants of Bone Mineral Density in Southern Chinese: (English)

          
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About the Book

This dissertation, "Genetic and Environmental Determinants of Bone Mineral Density in Southern Chinese" by Hoi-lun, Lau, 劉海倫, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Genetic and Environmental Determinants of Bone Mineral Density in Southern Chinese Submitted by Lau Hoi Lun for the degree of Doctor of Philosophy at the University of Hong Kong in July 2005 Bone mineral density (BMD), one of the risk factors for osteoporosis, is a complex trait determined by genetic and environmental factors. The genetic and environmental determinants of BMD were explored using two methods: the association study in a population-based cohort and the linkage and/or association analysis of 177 pedigrees with 674 subjects (each pedigree was identified through a proband having BMD Z score In the population-based cohort study, using stepwise multiple linear regression analysis, body weight was the strongest predictor for BMD in premenopausal women (n=262), accounting for 20% of the variance at the spine and hip regions. Other significant predictors were ERα IVS1-397T/C genotype at the spine; LRP5 2220C/T genotype at the spine and trochanter and age at menarche at trochanter. As for postmenopausal women (n=269), body weight ( 25% at various sites) and age ( 16% at hip regions) were the strongest predictors of BMD. Other significant predictors were age at menarche (4.4% at spine and 1% at hip region); weight bearing physical activity ( 1.5% at hip region); calcium intake ( 1% at hip regions); height (0.7% at trochanter); and ERβ 1082A/G genotype (0.8% at trochanter). In the family-based study, linkage and/or association of candidate genes were evaluated by the quantitative trait locus transmission disequilibrium test (QTDT) and MERLIN analysis. The heritability of BMD at the spine and hip was estimated to range between 40 to 80% by using SOLAR analysis. Years since menopause and isoflavone intake were significantly associated with BMD. ERβ genotype was found to have significant association and linkage with BMD. For within-family association, D14S1026 genotype of ERβ was associated with total hip BMD. Linkage analysis of all pedigrees revealed linkage of 1082A/G, 1730G/A and D14S1026 genotypes of ERβ with L1-4 BMD and femoral neck BMD; 1082A/G and D14S1026 genotypes of ERβ with total hip BMD; and IVS1-351A/G genotype of ERα with L1-4 BMD. In conclusion, a number of genetic and lifestyle factors were identified to affect BMD in this study. These findings imply that BMD at various sites and at different time span of a woman is modified by different genetic and lifestyle factors, suggesting that BMD is highly dependent on gene-environmental interactions.


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Product Details
  • ISBN-13: 9781361235065
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 244
  • Spine Width: 14 mm
  • Width: 216 mm
  • ISBN-10: 1361235063
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Language: English
  • Series Title: English
  • Weight: 853 gr


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