The Handbook of Dopamine captures current understanding of dopamine biology in the brain, including anatomical organization of dopamine neurons, their molecular and genetic diversity, synaptic and circuit connectivity, receptor function and signalling, through to diverse roles in behaviors and finally, dysfunction in disease. This volume compiles a comprehensive set of perspectives from a large number of leading scientists working in dopamine research. The volume describes the current state-of-the-field, summarizing knowledge that has been transformed in the last decade through the advent and application of sophisticated new technologies.

Table of Contents:
Section 1: Development, diversity, and connectivity 1. The dopamine system from an evolutionary perspective Sten Grillner and Brita Robertson 2. Molecular heterogeneity of midbrain dopamine neurons Rajeshwar Awatramani and Jean-Francois Poulin 3. Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons Huaibin Cai and Charles Gerfen 4. Anatomy of dopamine neuron projections: Axonal arbors, varicosities, and synapses Louis-Eric Trudeau and Raphaelle Denis 5. Dopamine neuron connectomes: Inputs and outputs Mitsuko Watabe-Uchida and Ryunosuke Amo Section 2: Dopamine neuron physiology and dopamine release regulation 6. Electrical patterns of activity in dopamine midbrain neurons in vivo Jochen Roeper, Birgit Liss, Zayd Khaliq, and Carmen C. Canavier 7. Computational modeling of midbrain dopamine neurons Carmen C. Canavier, Christopher Knowlton, Birgit Liss, Zayd Khaliq, and Jochen Roeper 8. Axonal dopamine release: Molecular mechanisms Pascal S. Kaeser 9. Somatodendritic dopamine release Margaret E. Rice, Takuya Hikima, Paul Witkovsky, and Jyoti C. Patel 10. Axonal regulation of dopamine transmission by striatal neuromodulators Stephanie J. Cragg, David Sulzer, and Kathryn Todd 11. Dopamine transporters and the nanoscale organization of the dopamine axon Aske Lykke Ejdrup, Matthew Lycas, Freja Herborg, and Ulrik Gether 12. Beyond dopamine: Cotransmission by dopamine neurons Riccardo Melani and Nicolas X. Tritsch Section 3: Dopamine signalling: Receptors, postsynaptic integration and plasticity 13. Unveiling activation mechanisms and intrinsic divergence of dopamine receptors based on experimentally determined structures Sung Joon Won, Kuo Hao Lee, and Lei Shi 14. Dopamine receptor drugs and their applications J. Robert Lane and Alessandro Bonifazi 15. Postsynaptic integration and plasticity in the striatum Sho Yagishita 16. Dopamine signaling roles in the extrastriatal basal ganglia Jerome Baufreton 17. Postsynaptic integration and plasticity in the prefrontal cortex Paul G. Anastasiades, Guillermo Gonzalez-Burgos, and Wen-Jun Gao Section 4: Dopamine mechanisms of learning and reinforcement 18. The dopamine reward prediction error signal Wolfram Schultz 19. Diversity of encoding: Reward to aversion Naoshige Uchida, Mitsuko Watabe-Uchida, and Isobel Green 20. Dopamine beyond temporal-difference reinforcement learning Kaue Machado Costa and Geoffrey Schoenbaum 21. Habits and dopamine Jay Bertran-Gonzalez and Bernard W. Balleine 22. Dopamine for performance evaluation—Insights from songbirds Vikram Gadagkar 23. Striking parallels between the dopaminergic systems of flies and mammals Kristijan D. Jovanoski and Scott Waddell 24. Reinforcement learning with dopamine: A convergence of natural and artificial intelligence Paul Masset and Samuel J. Gershman Section 5: Dopamine function in motivated behavior 25. Dopamine and the temporal control of behavior Joseph Paton 26. Volition and vigor Joshua T. Dudman and Luke T. Coddington 27. Why the new definition of “anhedonia” misses the mark on dopamine function: Studies of effort-based aspects of motivation and selection of voluntary physical activity John D. Salamone and Merce Correa 28. Exploration and behavioral variability Philippe Faure 29. Role of dopamine in adaptively tuning motivational bias to the current environment Roshan Cools, Hanneke E.M. Den Ouden, and Egbert Hartstra 30. Sex differences in dopamine systems involved in motivation and reward Christopher A. Turner, Noah Bass, Ivette L. Gonzalez, and Jill B. Becker 31. Dopamine and appetite Camila Saenz and Stephanie L. Borgland Section 6: Dopamine dysregulation: From neurology to psychiatry 32. Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson’s disease Enrico Zampese, James Moran, and D. James Surmeier 33. Understanding human dopamine neuron biology in Parkinson’s patient cells Gizem Onal, Maria Claudia Caiazza, Parnaz Sharifi, Iona Thomas-Wright, Johanna L. Hoffmann, Rachel Heon-Roberts, and Richard Wade-Martins 34. Dopamine replacement for Parkinson’s disease: Clinical approaches and experimental underpinnings M. Angela Cenci, Kristina Rosqvist, and Per Odin 35. Dopamine modulation of synaptic transmission in drug addiction Maria Reva and Christian L €Uscher 36. Molecular reprogramming of D1 and D2 dopaminoceptive medium spiny neurons in substance use disorder Caleb J. Browne and Eric J. Nestler 37. Human dopamine systems in addiction disorders Nora D. Volkow and Peter Manza 38. Apathy and impulsivity in neurological and psychiatric disorders Youssuf Saleh and Masud Husain 39. Dopamine dysfunction in psychosis Robert A. Mccutcheon and Chambrez-Zita Zauchenberger 40. Dopamine systems in impulsive–compulsive behavior Trevor W. Robbins and Jeffrey W. Dalley