This 2 volume set comprises of the 3rd edition of Volume 1 and the 4th edition of Volume 2, both published in 2014.

In recent years, we’ve developed a much better grasp of the biological and other factors associated with the development of obesity. New clinical trials, discoveries related to drug use, and greater understanding of the benefits of weight loss in obese patients have expanded the field of research in this area. Reflecting our evolving understanding of causes and consequences, the two-volume set Handbook of Obesity explores every facet of this disease from cause to cure.

Volume One: Epidemiology, Etiology, and Physiopathology provides comprehensive coverage of the biological, behavioral, and environmental determinants of this critical illness. This new edition is divided into five sections exploring essential factors involved in obesity research:

• History, Definitions, and Prevalence: Changes over time surrounding our notion of obesity, adiposity traits, and the epidemiology of obesity in various populations
• Biological Determinants of Obesity: Genetic and epigenetic evidence, fetal life and postnatal influences, the use of animal models in research, endocrine issues, molecular aspects, and issues related to viral infection and adiposity
• Behavioral Determinants of Obesity: The effects of food and ingestive behavior, smoking, breastfeeding, sleep duration, work/leisure time activity, and sedentary behavior
• Environmental, Social, and Cultural Determinants of Obesity: The role of agriculture and the food industry, the urban environment, social and economic aspects, cultural factors, environmental pollutants, and economic costs
• Consequences of Obesity: How excess weight affects and exacerbates a range of comorbid conditions, including diabetes, cardiovascular disease, pulmonary disorders, arthritis, and cancer

Volume Two: Clinical Applications explores essential factors involved in obesity prevention and treatment:

• Prevention of Obesity: Strategies such as reengineering the environment to encourage physical activity and prevent excessive weight gain in children and adults

• Evaluation of the Overweight or Obese Patient: Methods for assessing the overweight individual and the role of the primary care physician in patient management

• Medical Treatment of Obesity and Weight Management Issues in the Treatment of Obesity: Lifestyle for weight loss and weight maintenance, diet and exercise, medications, herbal agents, and issues related to childhood obesity

• Surgery: Screening for bariatric surgery, laparoscopic banding, liposuction, and other surgical techniques and strategies for operative and postoperative care

• Epilogue: The economic assessment and cost-effectiveness of treatments for obesity, how obesity is viewed internationally, and governmental responses to challenges arising from the growing prevalence of obesity

Presenting the insight of international experts and edited by two eminent leaders in obesity research, this two-volume set is essential for health care providers in search of a comprehensive and up-to-date guide to diagnosing and treating obese patients.

VOLUME ONE. History, Definitions, and Prevalence. Obesity Has Always Been with Us: An Historical Introduction. Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat. Anthropometric Indicators in Relation to the Gold Standards. Worldwide Prevalence of Obesity in Adults. Prevalence and Consequences of Pediatric Obesity. Obesity in Older Adults in the United States. Gender, Ethnic, and Geographic Variation in Adiposity. Biological Determinants of Obesity. Genetic Component to Obesity: Evidence from Genetic Epidemiology. Genes and the Predisposition to Obesity. Epigenetic Mechanisms in Obesity. Fetal and Early Postnatal Life Determinants of Adiposity. Animal Models of Obesity: Perspectives on Evolution of Strategies for Their Development and Analysis of Their Phenotypes. Animal Models of Obesity: Nonhuman Primates. CNS Regulation of Energy Balance. Gastrointestinal Regulation of Energy Balance. Gut Microbiome and Obesity. Sympathetic Nervous System and Endocrine Determinants of Energy Balance. Insulin Resistance and Obesity. White and Brown Adipose Tissue Development. Adipose Tissue Metabolism, Adipokines, and Obesity. Visceral Adipose Tissue and Ectopic Fat Deposition. Skeletal Muscle Metabolism and Obesity. Mitochondrial Bioenergetic Aspects of Obesity and Weight Loss. Resting Metabolic Rate, Thermic Effect of Food, and Obesity. Energy Cost of Exercise, Postexercise Metabolic Rates, and Obesity. Energy Partitioning, Substrate Oxidation Rates, and Obesity. Viral Infections and Adiposity. Behavioral Determinants of Obesity. Obesity: Influence of the Food Environment on Ingestive Behaviors. Obesity and Related Eating Disorders. Tobacco Use, Smoking Cessation, and Obesity. Breastfeeding and Later Obesity. Beverages and Obesity: Biology, History, Trends. Sedentary Time and Obesity. Occupational Work and Obesity. Leisure-Time Physical Activity and Obesity. Sustained Short Sleep and Risk of Obesity: Evidence in Children and Adults. Environmental, Social, and Cultural Determinants of Obesity. Role of Agriculture and the Food Industry in America’s Obesity. Transportation Policies and Obesity. Urban Environment, Building Design, and Obesity. Social and Economic Determinants of Obesity. Influence of Culture on Obesity. Bias, Discrimination, and Obesity. Environmental Chemicals and Obesity. Economic Costs of Obesity. Consequences of Obesity. Obesity and Mortality Rates. Obesity and Heart Disease. Obesity and Hypertension. Obesity and Lipoprotein Metabolism. Obesity and Type Diabetes. Obesity and Metabolic Syndrome. Obesity and Cancer: Clinical Epidemiology. Inflammatory Causes of Obesity and Metabolic Diseases. Obesity and Gallbladder Disease. Obesity and Liver: Cell Death, Compensatory Growth, and Repair of Damage. Obesity, Lung Function, and Lung Disease. Obesity, Arthritis, and Gout. Obesity and Mental Health. Obesity and Health-Related Quality of Life. Obesity and Pregnancy Outcomes. Obesity, an Inactive Lifestyle and Low Fitness: The Most Unhealthy Combination. Index. VOLUME TWO. Prevention of Obesity. Dietary Changes in Human Evolution: Implications for Prevention of Obesity; Prevention in Adults; Prevention of Obesity in Childhood and Adolescence; Reengineering the Built Environment: Progress in Schools, Work Sites, Neighborhoods, and Parks; Obesity and Evolution: Implications for Prevention of Type 2 Diabetes; Evaluation of the Overweight or Obese Patient. Classification and Evaluation of the Overweight Patient; Waist Girth: A Critical Evaluation of Usefulness; Genetic Evaluation of Patients with Syndromic and Nonsyndromic Obesity; Impact of Voluntary Weight Loss on Morbidity and Mortality; Obesity and the Primary Care Physician; Medical Treatment of Obesity and Weight Management Issues in the Treatment of Obesity: Behavior, Diet, Exercise and Medications. Behavioral Approaches to the Treatment of Obesity; Preventing Weight Regain after Weight Loss; Strategies to Reduce Calories in Food; Diet Composition and Weight Loss; Dietary Protein and Weight Management; Exercise and Weight Management; Drugs That Cause Weight Gain and Clinical Alternatives to Their Use; Sibutramine, Phentermine, and Diethylpropion: Sympathomimetic Drugs in the Management of Obesity; Drugs That Modify Fat Absorption and Alter Metabolism; Serotonin Receptor Modulation in the Treatment of Obesity; Combination Therapy: Topiramate and Phentermine; Bupropion plus Naltrexone (Contrave); Glucagon-Like Peptide- Agonists and Weight Regulation; Brown Adipose Tissue as a Target; Herbal and Alternative Approaches to Obesity; Is There a Future for Gene Therapy in Obesity? Special Issues in Treatment of Pediatric Obesity; Prevention and Management of Dyslipidemia, Hyperglycemia, and the Metabolic Syndrome in Obese Patients; Surgery. Surgical Procedures in the Treatment of Obesity and Its Comorbidities; Swedish Obese Subjects, SOS; Laparoscopic Adjustable Gastric Banding; Evolving Surgical Therapy for Obesity; Liposuction and Obesity; Mechanisms Underlying the Endocrine Management of Postbariatric Surgical Patients; Epilogue. Cost-Effectiveness of Obesity Prevention and Treatment; Government’s Evolving Role: Nutrition, Education, Regulation, Monitoring, and Research; Index.