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Handbook of Process Chromatography: Development, Manufacturing, Validation and Economics

Handbook of Process Chromatography: Development, Manufacturing, Validation and Economics

          
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About the Book

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments

Table of Contents:
PrefaceAcknowledgements1. Biopharmaceuticals Today2. Process Capability and Production Scenarios3. Process Design Concepts4. Separation Technologies5. Analysis6. Cleaning and Sanitization7. Validation8. Economics9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles10. Optimization of Chromatographic Separations11. Equipment12. Column PackingAppendix A. Symbols and Definitions in Liquid ChromatographyAppendix B. Dimensionless NumbersAppendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian CellsAppendix D. Simulations Using the Supplied Software


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Product Details
  • ISBN-13: 9780123740236
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Depth: 25
  • Height: 243 mm
  • No of Pages: 382
  • Spine Width: 20 mm
  • Weight: 940 gr
  • ISBN-10: 0123740231
  • Publisher Date: 25 Oct 2007
  • Binding: Hardback
  • Edition: 0002-
  • Language: English
  • Series Title: English
  • Sub Title: Development, Manufacturing, Validation and Economics
  • Width: 165 mm


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