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Handbook on Syntheses of Amino Acids

Handbook on Syntheses of Amino Acids

          
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About the Book

Amino acid synthesis is a field of research that has existed for over 150 years, but renewed interest has led to an exponential increase in publications in the past two decades. The Handbook on Syntheses of Amino Acids provides a comprehensive survey of synthetic procedures that prepare
natural and unnatural amino acids in both racemic and optically active forms. The book begins with an introduction to amino acids, their properties, and analytical techniques, including a detailed examination of methods used to establish enantiomeric configuration and optical purity. The next two
chapters focus on processes for preparing racemic amino acids, divided into those syntheses that introduce the amino and/or carboxy groups, and those that introduce the side chain. While some of these procedures date from the 1800s, modified versions are still extensively employed. A key component
of these chapters is tables that summarize the many compounds made by each method. A chapter devoted to 2,3-dehydroamino acids provides the bridge between racemic and asymmetric syntheses, as dehydroamino acids are themselves achiral, but can be transformed into optically active products. Asymmetric
amino acid preparations are then divided into six chapters, based on methods that introduce the amino and/or carboxy groups, those that introduce the side chains to acyclic synthons, those that introduce side chain to cyclic templates, those that open small ring systems, and those that derive the
amino acid from other amino acids (with a separate chapter for serine-derived products). The growing field of non-alpha-amino acid synthesis is addressed in a separate chapter . The book is completed by a discussion of amino acid modifications, including resolutions, N-alkylations, amidations and
peptide couplings.

About the Author:
Mark Blaskovich is Chief Operating Officer at Mimetica, a peptidomimetic drug discovery company. An experienced industrial medicinal chemist, Mark has worked for CEPTYR Inc and the former peptide mimetics company Molecumetics.


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Product Details
  • ISBN-13: 9780841272194
  • Publisher: Oxford University Press, USA
  • Publisher Imprint: Oxford University Press, USA
  • Depth: 64
  • Language: English
  • Returnable: Y
  • Spine Width: 65 mm
  • Weight: 2405 gr
  • ISBN-10: 0841272190
  • Publisher Date: 21 May 2010
  • Binding: Hardback
  • Height: 258 mm
  • No of Pages: 1328
  • Series Title: An American Chemical Society Publication
  • Sub Title: General Routes for the Syntheses of Amino Acids
  • Width: 183 mm


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