Human Chorionic Gonadotropin (hCG)

Human Chorionic Gonadotropin (hCG)

          
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About the Book

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

Table of Contents:
INTRODUCTION Chapter 1: THE EXPANDING WORLD OF hCG Robert Hussa Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES Laurence Cole Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION Laurence Cole GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG Chapter 4: THE MOLECULAR GENETICS OF hCG Stephen Butler Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG Laurence Cole, PhD and Stephen Butler Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG Laurence Cole Chapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT Laurence Cole Chapter 8: GLYCOBIOLOGY OF hCGAkira Kobata Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNITLaurence Cole Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCGLaurence Cole BIOLOGICAL FUNCTION OF hCG Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS CV Rao Chapter 12: THE hCG RECEPTOR Laurence Cole and Stephen Butler Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCGLaurence Cole Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER Steven Butler and Ray Iles CLINICAL APPLICATIONS Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTIONCisco Byrn Chapter 16: hCG IN THE IVF CLINICErvin Jones, Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM Laurence Cole hCG TESTS Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTSLaurence Cole Chapter 19: QUANTITATIVE hCG ASSAYSLaurence Cole Chapter 20: FALSE-POSITIVE hCG ASSAYS Laurence Cole Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYSLaurence Cole Chapter 22: POINT-OF-CARE PREGNANCY TESTS Laurence Cole Chapter 23: OVER-THE-COUNTER PREGANCY TESTS Laurence Cole Chapter 24: hCG STANDARDS Ulf Stenman TEST APPLICATIONS Chapter 25: BACKGROUND hCG Laurence Cole Chapter 26: PREGNANCY TESTINGLaurence Cole Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES Laurence Cole Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA Laurence Cole Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES Laurence Cole Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS Laurence Cole and Carolyn Muller Chapter 31: PITUITARY hCG AND FAMILIAL hCG Laurence Cole Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES Laurence Cole BASIC METHODS Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS Laurence Cole Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG Laurence Cole Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES Laurence Cole EVOLUTION, SUMMARY AND THE FUTURE Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCERLaurence Cole Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULELaurence Cole Chapter 38: hCG AND THE FUTURE Laurence Cole


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Product Details
  • ISBN-13: 9780123849076
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Elsevier Science Publishing Co Inc
  • Depth: 37
  • Language: English
  • Returnable: N
  • Spine Width: 24 mm
  • Width: 152 mm
  • ISBN-10: 0123849071
  • Publisher Date: 21 Sep 2010
  • Binding: Hardback
  • Height: 229 mm
  • No of Pages: 400
  • Series Title: English
  • Weight: 740 gr


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