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Immunogenicity and Safety of Trivalent Versus Quadrivalent Seasonal Influenza Vaccine: A Systematic Review(English)

Immunogenicity and Safety of Trivalent Versus Quadrivalent Seasonal Influenza Vaccine: A Systematic Review(English)

          
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About the Book

This dissertation, "Immunogenicity and Safety of Trivalent Versus Quadrivalent Seasonal Influenza Vaccine: a Systematic Review" by Uditha Wathsala, Makawita Appuhamilage, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The substantial burden on health care and society due to seasonal influenza epidemic is well evident and is further aggravated by continuous mismatch of B linage, between circulating B linage and trivalent vaccine (TIV) contained B linages, across all ages. As such World Health Organization (WHO) recommended to include additional B linages in the seasonal influenza vaccine in 2013, since then increased trend for quadrivalent influenza vaccine (QIV) has been observed among most of the developed countries to broaden the protection against all four influenza strains. But considerable uncertainty still remains to use QIV over TIV, due to limited evidence on immunogenicity and safety of QIV versus TIV. Hence assessing non-inferiority of QIV versus TIV in terms of immunogenicity and comparable safety profile of QIV versus TIV in this systematic review, provides solid evidence for selection of seasonal influenza vaccine for all ages in terms of preventing flu epidemic around the world. The studies only in the English language were identified searching "PubMed" data base using EndNote software without a defined time period. The descriptive immunogenicity of QIV and TIV were assessed for criteria recommended by the Centre for Biologics Evaluation and Research (CBER) /Committee for Medicinal Products for Human Use (CHMP) in terms of post vaccination percentage of Sero Conversion Rate (SCR%), Sero Protection Rate (SPR%), Sero Conversion Factor (SCF) value and Geometric Mean Titer (GMT) value from Heamagglutination Inhibition (HI) assay. The non-inferiority for shared strain and superiority for alternate B linage of QIV versus TIV was assessed by the GMT ratio with 95%CI. The SCR difference was used as an optional criteria for assessing non-inferiority and superiority of QIV versus TIV. The solicited injection site and general adverse events (AE), Serious AEs and Medical attended AEs were safety outcomes. Twelve Randomized Controlled Trials were identified across three age groups as infants18 years old. The inactivated, adjuvant (AD) and live attenuated (LA) formulation of both QIV and TIV were included. The intramuscular (IM), intradermal (ID) and intranasal route were identified as route of administration of both vaccines across all studies. All QIVs in children and adults met CBER criteria against four influenza strain, except study on infant where this criteria was not applicable. All TIVs met given criteria for both types A strains and homologous B linages as a vaccine strain in children 3-17yeras and adults>18 years except one study. QIV was shown to be more immunogenic against alternate B linage compared to TIV both in children and adults in terms of terms of post vaccination GMT value, SCR% and SCF value. This observation was more notable in children 3-17 years compared to adults >18 years. Elderly groups> 61 years elicited lower post vaccination GMT and SCF value compared to adults18-60 years for all three vaccine types. QIV shown to be non-inferior to TIV for shared strain and superior for alternate B linage in terms of adjusted GMT ratio for all ages except two studies in infant


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Product Details
  • ISBN-13: 9781361020586
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 62
  • Spine Width: 3 mm
  • Weight: 168 gr
  • ISBN-10: 136102058X
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Series Title: English
  • Sub Title: A Systematic Review
  • Width: 216 mm


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Immunogenicity and Safety of Trivalent Versus Quadrivalent Seasonal Influenza Vaccine: A Systematic Review(English)
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