Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount. This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities. This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike.

Table of Contents:
1. General overview/introduction by co-editors, with a historical perspective Section I. Ketogenic Diet for Epilepsy in the Clinic 2. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update 3. 'Alternative' Ketogenic Diets 4. Ketogenic Diet Therapies in Adults: History, Demand, and Results 5. How Do You Implement the Diet? 6. Glut1 Deficiency Syndrome and the Ketogenic Dietary Therapies 7. Ketogenic Diet in Established Epilepsy Indications 8. Ketogenic Diet for Other Epilepsies 9. The Ketogenic Diets in Idiopathic Generalized Epilepsy Syndromes 10. Ketogenic Diet Therapy for Infants with Pharmacoresistant Epilepsy and/or Metabolic Disease 11. Ketogenic Diet in Status Epilepticus 12. Preventing Side Effects and Diet Discontinuation Section II. Ketogenic Diet: Emerging Clinical Applications and Future Potential 13. Overview: Expanded Uses of Ketogenic Therapies 14. Metabolism-Based Treatments for Managing Cancer: Scientific Rationale 15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer 16. Ketogenic Diet, Social Behavior, and Autism: Insights from Animal Models 17. Ketotherapeutics to Rescue Brain Energy Deficits: An Emerging Strategy to Delay Cognitive Decline in Alzheimer's Disease 18. Ketogenic Diet and Ketones for Improving Neurological Outcomes after Acute Neurotrauma 19. Ketogenic Diets and Neuroinflammation 20. The Ketogenic Diet in the Treatment of Schizophrenia 21. The Ketogenic Diet and the Gut Microbiome Section III. Ketogenic Diet in the Laboratory 22. Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms 23. Ketogenic Diet and PPARy 24. Ketogenic Diet and Adenosine in Epilepsy - Models and Mechanisms 25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis 26. Ketogenic Diet, Aging, and Neurodegeneration 27. Metabolic Seizure Resistance via BAD and KATP Channels 28. Lactate Dehydrogenase: a Novel Metabolic Target 29. Effects of the Ketogenic Diet on the Blood-Brain Barrier 30. Metabolic and Redox Alterations by Ketogenic Diets 31. Nicotinamide Adenine Dinucleotide as a Central Mediator of the Ketogenic therapy Section IV. Ketone-Based Metabolism: General Health and Metabolic Alternatives 32. Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives 33. Ketone Supplementation for Health and Disease 34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-evoked Ketosis 35. Amino Acids in the Treatment of Neurological Disorders 36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet 37. Triheptanoin in Epilepsy and Beyond 38. Anti-seizure and Anti-epileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose 39. Low Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity 40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery and Adaptation 41. Advancing the Awareness and Application of Metabolic and Ketogenic Therapies Globally and Offering Hope