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Kif5b May Play a Role in Impairing Mouse Memory: A Behaviour and Cellular Study(English)

Kif5b May Play a Role in Impairing Mouse Memory: A Behaviour and Cellular Study(English)

          
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About the Book

This dissertation, "Kif5b May Play a Role in Impairing Mouse Memory: a Behaviour and Cellular Study" by Yangjun, Lin, 林扬骏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Alzheimer's Disease is one of the most fearsome diseases worldwide. The study of Alzheimer's Disease (AD) is broad and many have focused on investigating the various proteins involved in neurons. A popular hypothesis of the cellular mechanism of AD is the accumulation of beta-Amyloid. Kinesin is a large group of motor proteins, which plays an extensive role in mitosis and intracellular cargo transport, including that of the Amyloid Protein Precursor. In the present study we have performed fear conditioning behaviour tests on Kif5b conditional knockout (CKO) mouse. Kif5b CKO mouse shows an impair contextual memory compared to the wild type, but does not display an impaired auditory memory. Heterozygous Kif5b knock out mouse shows no significant difference to the wild type. The study has also generated Kif5b fragments and used them to pull-down proteins in mouse brain lysate. The study has identified Clathrin and alpha-Adaptin as binding partners of Kif5b in mouse neuronal cells. The binding domain of Kif5b for these proteins is between amino acid residue 891-935. Finally this study has made a number of recommendations for further study. DOI: 10.5353/th_b5091448 Subjects: Memory disorders - Animal models Kinesin


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Product Details
  • ISBN-13: 9781361008881
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 44
  • Spine Width: 6 mm
  • Weight: 404 gr
  • ISBN-10: 1361008881
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Language: English
  • Series Title: English
  • Sub Title: A Behaviour and Cellular Study
  • Width: 216 mm


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