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The Lancet Handbook of Essential Concepts in Clinical Research

The Lancet Handbook of Essential Concepts in Clinical Research

          
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About the Book

Building on articles previously published in The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods in epidemiology. The needs of clinicians predominate throughout the text, but these needs overlap with those of researchers especially in chapters covering randomized controlled trials. For readers to assess trials accurately they need to understand relevant guidelines on the conduct of trials that are emerging from methodological research. In presenting these discussions to clinicians these chapters will help researchers who also do randomized trials and provide a methodological background that enhances the quality and quantity of their research productivity. Enables clinicians to read the medical literature more critically Chapters cover: descriptive studies, cohort studies, case control studies, bias, and screening tests Five chapters dedicated to randomized controlled trials

Table of Contents:
An overview of clinical research: the lay of the land. Descriptive studies: what they can and cannot do. Bias and causal associations in observational research. Cohort studies: marching towards outcome. Case-control studies: research in reverse. Generation of allocation sequences in randomized trials: chance, not choice. Allocation concealment in randomized trials: defending against deciphering. Sample size slippages in randomized trials: exclusions and the lost and wayward. Blinding in randomized trials: hiding who got what. Uses and abuses of screening tests. Unequal group sizes in randomized trials: guarding against guessing. Sample size calculations in randomized trials: mandatory and mystical. Compared to what? Finding controls for case-control studies. Refining clinical diagnosis with likelihood ratios. Multiplicity in randomized trials I: endpoints and treatments. Multiplicity in randomized trials II: subgroup and interim analyses.


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Product Details
  • ISBN-13: 9780080448664
  • Publisher: Elsevier Health Sciences
  • Publisher Imprint: Elsevier / The Lancet
  • Depth: 13
  • Height: 235 mm
  • No of Pages: 242
  • Series Title: The Lancet Handbooks
  • Weight: 295 gr
  • ISBN-10: 0080448666
  • Publisher Date: 11 Apr 2006
  • Binding: Paperback
  • Edition: 1
  • Language: English
  • Returnable: N
  • Spine Width: 11 mm
  • Width: 187 mm


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