This book explores the rapidly advancing field of gut–brain interactions, with a particular focus on the emerging evidence linking the gut microbiome to neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, cerebral palsy, and amyotrophic lateral sclerosis (ALS). As scientific discoveries continue to illuminate how gut microorganisms influence brain structure and function, this work examines the mechanisms through which microbial imbalance contributes to disease onset and progression. By integrating cutting-edge findings on neuroinflammation, immune modulation, metabolic signaling, and neurotransmitter regulation, the book provides a comprehensive analysis of how the gut microbiome may act not only as a contributing factor but also as a promising therapeutic target. Each chapter highlights how disturbances in gut microbial ecology can trigger neuroinflammation, cognitive impairment, and motor neuron degeneration, while also presenting emerging therapeutic strategies including probiotics, prebiotics, dietary interventions, and fecal microbiota transplantation. Ultimately, this book offers an optimistic perspective on the development of microbiome-based, personalized interventions that hold the potential to transform the prevention and treatment of neurological disorders.
Table of Contents: Part I.- Chapter 1. The Microbiome-Body Connection: Unveiling the Gut-Brain Axis.- Chapter 2. Gut Microbiome Imbalance: The Root Cause of Neurodegeneration?.- Chapter 3. The Vagally Mediated Pathway: How Gut Signals Affect the Nervous System.- Chapter 4. Parkinson’s Disease and the Microbiome: A New Frontier for Early Diagnosis.- Chapter 5. ALS and the Microbiome: Understanding the Gut’s Impact on Motor Neuron Degeneration.- Chapter 6. The Gut microbiomes alterations in children with cerebral palsy and Epilepsy.- Chapter 7. The Microbiome and Neurotransmitter Regulation: A Double-Edged Sword.- Chapter 8. Therapeutic Interventions: Modulating the Microbiome to Combat Neurodegeneration.- Part II.- Chapter 9. The Role of Inflammation in the Brain: A Gut-Driven Phenomenon.- Chapter 10. Gut microbiome and Bile acid interactions: Role play changing neuropsychiatric illnesses.- Chapter 11. Gut Dysbiosis in Alzheimer's Disease: Insights from the Microbiome.- Chapter 12. Gut microbiome, Machine learning and Artificial Intelligence way forward with precision medicine.- Chapter 13. Altering gut microbiome interactions: Clinical trial results and implications.- Chapter 14. Looking Ahead: The Promise of the Gut Microbiome in Personalized Neurodegenerative Disease Therapies.- Chapter 15. Gut microbiome in chronic disorders management.- Chapter 16. Gut microbiome changing foods and nutrition.
