Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Gynaecology and obstetrics > Microenvironmental Regulation of Endometrial Stem Cells: (English)
Microenvironmental Regulation of Endometrial Stem Cells: (English)

Microenvironmental Regulation of Endometrial Stem Cells: (English)

          
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About the Book

This dissertation, "Microenvironmental Regulation of Endometrial Stem Cells" by Mingzhu, Cao, 曹明珠, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled MICROENVIRONMENTAL REGULATION OF ENDOMETRIAL STEM CELLS Submitted by CAO Mingzhu for the degree of Doctor of Philosophy at The University of Hong Kong in January, 2015 The endometrium is a dynamic tissue undergoing regular regeneration. In humans and mice, a population of endometrial stem/progenitor cells is responsible for the cyclical remodeling of the tissue. Adult stem cells reside in a specialized niche that regulates the fate of the stem cells. Our understanding of the microenvironmental regulation of endometrial stem/progenitor cells is limited. This project hypothesize that myometrial cells are niche component of the endometrial stem cells maintaining their self-renewal capacity. The first objective of this study was to characterize the mouse endometrial stem/progenitor cells during uterine remodeling in pregnancy. Using bromodeoxyuridine (BrdU) labeling pulse-chase technique, putative mouse I endometrial stem cells were identified by their ability to retain the label after a long chase period. The label-retaining stromal cells (LRSC) were localized primarily to three locations: myometrium-endometrium junction, beneath luminal epithelium, and adjacent to blood vessels. They expressed CD140b, CD146, CD44, CD90 and Sca-1, suggesting that they were of mesenchymal origin. During pregnancy, non-proliferating LRSC predominately resided at the inter-implantation site of the endometrium. Immediately after parturition, a + + significant portion of the LRSCs (43.89%) underwent proliferation (BrdU /Ki-67 ) and expressed total and active β-catenin. The expression of β-catenin in the LRSCs was transiently elevated at postpartum day 1 (PPD1). Proliferation of the LRSCs resulted in a significant decline in the proportion of LRSC in the postpartum uterus. The LRSCs became dormant again at PPD7, and the percentage of LRSC remained stable thereafter. The second objective was to examine the effect of human myometrial cells in the regulation of endometrial mesenchymal-like stem cells (eMSCs), which were identified by coexpression of CD140b and CD146. In vitro co-culture of myometrial cells with eMSCs enhanced the colony forming and self-renewal abilities of eMSCs when compared with culture of eMSC alone. The coculture effects were observed even when there was no direct contact between the myometrial cells and the eMSCs, indicating that the myometrial cells derived secretory factor(s) were responsible for maintaining the stem cell properties of eMSCs in vitro, including expression of endometrial mesenchymal stem cell II phenotypic markers, short and long-term expansion and multipotency. The third objective was to investigate the potential molecular signals from myometrial cells on maintenance of eMSCs. Concentrated high molecular weight molecules secreted by the human myometrial cells enhanced the colony forming ability and stem cell phenotypes of eMSCs. Activation of the Wnt/β-catenin signaling pathway promoted the clonogenicity and self-renewal ability of eMSCs, whilst inhibitor of Wnt/β-catenin signaling reversed the effects. Using centrifugal filter devices, liquid chromatography, SDS-PAGE and mass spectrometry analysis, 5 proteins in the spent medium of myometrial cells culture were identified. One of them, matrix metalloproteinase 3 (MMP3) was known to be involved in regenerative events of the endometrium. Preliminary data revealed that anti-MMP3 antibody


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Product Details
  • ISBN-13: 9781361024171
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 274
  • Spine Width: 15 mm
  • Width: 216 mm
  • ISBN-10: 1361024178
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Series Title: English
  • Weight: 640 gr


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