Home > Mathematics and Science Textbooks > Chemistry > Modeling Microtubule Dynamic Instability.: (English)
Modeling Microtubule Dynamic Instability.: (English)

Modeling Microtubule Dynamic Instability.: (English)

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist
X

About the Book

Microtubules are non-covalent polymers important for many processes such as vesicle trafficking and establishment of cell polarity and essential for cell division. A key property of microtubules is that they are highly dynamic. Microtubules constantly switch between phases of growth and shortening. This behavior is called dynamic instability. Although the importance of dynamic instability is well established from a cell-biological point of view, its regulation and mechanistic details are poorly understood. This doctoral thesis summarizes an effort to better understand dynamic instability by means of an interdisciplinary approach. The opening chapter presents an overview of microtubule dynamics and its pending questions. Then, an introduction to stochastic modeling in biology is presented for readers of diverse background. The dynamics of the microtubule network is then studied with a model at a mesoscopic scale (coarse grain) and a model at a microscopic scale (fine details). The mesoscopic modeling results indicate that many behaviors thought to require regulatory proteins are instead unavoidable outcomes of the physical constraints on a system of nucleated polymers competing in a confined space. This suggests that regulatory proteins tune microtubule dynamics rather than govern it. This conclusion has important evolutionary implications as microtubules are present in all eukaryotes and therefore their underlying mechanistic principles must be robust. The microscopic model is the first one built Ivan Gregoretti at a the dimer scale to recapitulate dynamic instability. With this model, the mechanistic details of the once paradoxical microtubule dilution experiments are shown. As opposed to the canonical view, the microscopic model indicates that interprotofilament cracks are always present, even when the microtubule is growing, and it also indicates that there is GTP-tubulin binding to the shortening microtubule. Quantitative analysis concludes that it is the relationship between the lengths of cracks and the GTP cap what dictates microtubule dynamics, not the GTP cap alone. With its simulation speed and level of detail, the microscopic scale model finally opens the door to testing hypotheses of the mechanisms used by microtubule regulatory proteins.


Best Sellers


Product Details
  • ISBN-13: 9781243446879
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • No of Pages: 210
  • Series Title: English
  • Weight: 426 gr
  • ISBN-10: 1243446870
  • Publisher Date: 02 Sep 2011
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 14 mm
  • Width: 203 mm


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Modeling Microtubule Dynamic Instability.: (English)
Proquest, Umi Dissertation Publishing -
Modeling Microtubule Dynamic Instability.: (English)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Modeling Microtubule Dynamic Instability.: (English)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA