This one-stop reference for everyone working in the agrochemical business is the leading reference in the field, with first-class authors from all major crop protection companies, including Bayer, Dow, Syngenta and BASF. In three volumes, one each on herbicides, fungicides and insecticides, it provides up-to-date information on the chemical properties, mode of action, range of application, industrial-scale synthesis and commercial products. The new edition has been updated and expanded by more than 50 new compounds and their mechanisms, for a complete picture of agrochemicals introduced since 1990. A truly comprehensive source of top quality information.

Table of Contents:
VOLUME 1: HERBICIDES Overview HRAC CLASSIFICATION OF HERBICIDES AND RESISTANCE DEVELOPMENT Introduction HRAC Classification System of Herbicides Herbicide Resistance ACETOHYDROXYACID SYNTHASE INHIBITORS (AHAS/ALS) Biochemistry of the Target and Resistance Newer Sulfonylureas Imidazolinone Herbicides Triazolopyrimidines Pyrimidinylcarboxylates and Sulfonanilides Sulfonylaminocarbonyl-Triazolinones PROTOPORPHYRINOGEN IX OXIDASE INHIBITORS Introduction Historical Development Non-Classical Protox Chemistries Recent Developments Toxicology Summary HERBICIDES WITH BLEACHING PROPERTIES Phytoene Desaturase Inhibitors Hydroxyphenylpyruvate Dioxygenase (HPPD): The Herbicide Target Triketones Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibitors: Heterocycles NEW AUXIN MIMICS AND HERBICIDES The Molecular Mode of Action of Auxin Herbicides Aminopyralid Pyrimidine Carboxylic Acids, Aminocyclopyrachlor HERBICIDES DISTURBING THE SYNTHESIS OF VERY LONG-CHAIN FATTY ACIDS (VLCFAs) Inhibitors of the Synthesis of Very Long-Chain Fatty Acids (VLCFAs) Chemistry and Biology of Oxyacetamides, Tetrazolinones, and Triazolinones Isoxazolines INHIBITORS OF CELLULOSE BIOSYNTHESIS Introduction Cellulose Biosynthesis Inhibitors from Different Chemical Substance Classes Cellulose Biosynthesis Inhibitors from Natural Sources SAFENERS FOR HERBICIDES Introduction Overview of Selected Safeners Mechanisms of Herbicide Safener Action Mode of Action of Safeners in Agricultural Practice Concluding Remarks GENETICALLY MODIFIED HERBICIDE-RESISTANCE CROPS Overview Inhibitors of 5-Enolpyruvyl Shikimate 3-Phosphate Synthase (EPSPS) Glutamine Synthetase Inhibitors MICROTUBULIN ASSEMBLY INHIBITORS (PYRIDINES) Introduction Biology of the Microtubulin Assembly Inhibitors (Pyridines) Environmental Fate of Microtubulin Assembly Inhibitors (Pyridines) Toxicology of Microtubulin Assembly Inhibitors (Pyridines) Mode of Action of Microtubulin Assembly Inhibitors (Pyridines) Synthesis of Dithiopyr and Thiazopyr ACETYL-CoA CARBOXYLASE INHIBITORS Introduction Biochemistry Chemistry of ACCase Inhibitors Structure-Activity Relationships Pinoxaden Summary and Outlook PHOTOSYNTHESIS INHIBITORS: REGULATORY ASPECTS, RE-REGISTRATION IN EUROPE, MARKET TRENDS, AND NEW PRODUCTS Introduction The Re-Registration in the European Union Main Changes in Guidelines Regarding EU RE-Registration New Regulations in Europe Situation of PS II Inhibitors in the EC Markets Current Market Share of PS II Compound Groups A New Herbicide for Corn and Sugarcane: Amicarbazone - BAY MKH Conclusions NEW ASPECTS OF PLANT REGULATIONS Introduction Plant Growth Regulators PGRs in Modern Agriculture Conclusions and Developments VOLUME 2: FUNGICIDES Overview FRAC MODE OF ACTION CLASSIFICATION AND RESISTANCE RISK OF FUNGICIDES History of Fungicide Use Fungicides: Importance of Individual Modes of Action Fungicide Resistance Fungicides Classes and Modes of Action FUNGICIDES ACTING ON OXIDATIVE PHOSPHORYLATION The Biochemistry of Oxidative Phosphorylation: A Multiplicity of Targets for Crop Protection Chemistry Strobilurins and Other Complex III Inhibitors Succinate Dehydrogenase Inhibitors Uncouplers of Oxidative Phosphorylation NADH Inhibitors (Complex I) FUNGICIDES ACTING ON AMINO ACIDS AND PROTEIN SYNTHESIS Natural Compounds Used in Agriculture Interfering in Protein Synthesis of Fungi and Bacteria Anilinopyrimidines: Methionine Biosynthesis Inhibitors FUNGICIDES ACTING ON SIGNAL TRANSDUCTION Mode of Action Chemistry and Biology of Fludioxonil, Fenpiclonil, and Quinoxyfen FUNGICIDES ACTING ON MITOSIS AND CELL DIVISION Zoxamide: An Antitubulin Fungicide for the Control of Oomycete Pathogens Pencycuron: A Phenylurea Fungicide for Rhizoctonia solani STEROL BIOSYNTHESIS INHIBITORS Sterol Biosynthesis Inhibitor SBI Fungicides in Agriculture SBI Class I: DMI Fungicides SBI Class II: Amines SBI Class III: Hydroxyanilides SBI Class IV: Squalene Epoxidase Inhibitors CARBOXYLIC ACID AMIDE (CAA) FUNGICIDES Introduction Chemistry of the Carboxylic Acid Amides Biological Activity of Carboxylic Acid Amides Mode of Action and Mechanism of Resistance of the CAA Fungicides FLUOPICOLIDE: A NEW ANTI-OOMYCETES FUNGICIDE? Introduction Chemical and Physical Properties Toxicology/Ecotoxicology Spectrum of Activity Effect of Fluopicolide on Spectrin-Like Protein Distribution Conclusion MELANIN SYNTHESIS IN THE CELL WALL Biological Occurrence and Function of Melanin in Fungi Overview: Fungicides Inhibiting DHN Melanin Biosynthesis Biology of Scytalone Dehydratase Inhibitors Biochemical Reaction Mechanim of Scytalone Dehydratase and Structure-Based Inhibitor Design Chemistry and Stereochemistry of Carpropamid Resistance Problems and Successful Management in Japan Final Remarks FUNGICIDES WITH UNKNOWN MODE OF ACTION Introduction Cymoxanil Fosetyl-Aluminum Flusulfamide Diclomezine Triazoxide Tebufloquin RECENTLY INTRODUCED POWDERY MILDEW FUNGICIDES Introduction Cyflufenamid Metrafenone Pyriofenone Proquinazid Flutianil Conclusions NEWEST ASPECTS OF NUCLEIC ACID SYNTHESIS INHIBITORS: METALAXYL-M Introduction Chemistry of Metalaxyl-M/Mefenoxam Biological Activity Mode of Action and Mechanism of Resistance Degradation and Metabolism of the Two Enantiomers HOST DEFENSE INDUCERS Introduction General Mechanism of Induced Resistance Market Products Summary and Outlook VOLUME 3: INSECTICIDES Overview IRAC: Insecticide Resistance, and Mode of Action Classification of Insecticides Introduction Objectives of the IRAC Structure and Organization of the IRAC Activities Principles of Resistance The Mode of Action (MoA) Classification Scheme v7.0, August 2010 Effective IRM Strategies and Approved Principles Future Market Trends Conclusions INSECT MOLTING AND METAMORPHOSIS Bisacylhydrazines: Novel Chemistry for Insect Control Pyriproxyfen: A New Juvenoid CHITIN SYNTHESIS Chitin Synthesis and Inhibitors Mite Growth Inhibitors: Clofentezine, Hexythiazox, Etoxazole MIDGUT - TRANSGENIC CROPS EXPRESSING Bacillus thuringiensis CRY PROTEINS Introduction Plant Engineering Insecticidal Crystal Proteins from B. thuringiensis Bt Plants Insect Resistance to Bt Resistance Management with Bt Plants Safety of Bt Plants Conclusions METABOLIC PROCESSES Inhibitors of Oxidative Phosphorylation Inhibitors of Oxidative Phosphorylation via Disruption of the Proton Gradient Inhibitors of Mitochondrial Electron Transport: Acaricides and Insecticides Inhibitors of Lipid Synthesis: Acetyl-CoA-Carboxylase Inhibitors NERVOUS SYSTEM Nicotinic Acetylcholine Receptor Agonists: Target and Selectivity Aspects Chemical Structural Features of Commercialized Neonicotinoids Sulfoxaflor Spinosad and Spinetoram, a New Semi-Synthetic Spinosyn Sodium Channel-Blocking Insecticides Ligand-Gated Chloride Channel Antatgonists (Fiproles) Chloride Channel Activators/New Natural Products: Avermectins and Milbemycins NEW UNKNOWN MODES OF ACTION Selective Feeding Blockers: Pymetrozine, Flonicamid, and Pyrifluquinazon Acaricides with Undefined Mode of Action: Bifenazate, Cyflumetofen, and Amidoflumet Pyridalyl: Discovery, Insecticidal Activity, and Mode of Action Recent Nematicides INSECTICIDES AFFECTING CALCIUM HOMEOSTASIS Ryanodine Receptor Modulators: Diamides Flubendiamide Anthranilic Diamide Insecticides: Chlorantraniliprole and Cyantraniliprole Index of Common Names Subject Index