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Molecular Diagnostics: For the Clinical Laboratorian

Molecular Diagnostics: For the Clinical Laboratorian

          
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About the Book

In this newly updated, second edition of Molecular Diagnostics, notable practitioners describe how laboratory medicine is practiced today and illuminate how it will function tomorrow as the revolutionary advances afforded by molecular diagnostics become increasingly central to effective analysis. Proceeding from a discussion of elementary nucleic acid technology to a review of the more advanced techniques, the distinguished contributors lay the groundwork for a comprehensive understanding of their applications throughout clinical medicine. This new edition contains new chapters on bioinformatics. microarrays, methylation assays, FISH. laser capture microdissection, quality assurance, chimerism studies for bone marrow transplantation, and separate chapters on genetic counseling and ELSI (ethical, legal, and social issues). These new chapters represent developments in the past decade that have fundamentally changed the scope from molecular pathology to molecular diagnosis, highlighting the changing role of the clinical laboratorians who direct these efforts.

Table of Contents:
Part I. Introduction; An Historical Perspective on the Clinical Diagnostic Laboratory; Robert E. Moore; Part II. Basic Molecular Biology; An Overview of Nucleic Acid Biochemistry, Structure, and Function: The Foundations of Molecular Biology; William B. Coleman; Extraction of Nucleic Acids; Paul N. Bogner and Anthony A. Killeen; Nucleic Acid Blotting Techniques: Theory and Practice; Terry Amiss and Sharon Collins Presnell; The Polymerase Chain Reaction; William B. Coleman and Gregory J. Tsongalis; Bioinformatics: Computer-Based Approaches to Genetic Analysis; Sharon L. Ricketts; Part III. Molecular Diagnostic Technologies; PCR-Based Methods for Mutation Detection; Ian M. Frayling, Emma Monk, and Rachel Butler; Alternative Methods for Amplified Nucleic Acid Testing; Deborah A. Payne; Electrophoretic Methods for Mutation Detection and DNA Sequencing; W. Edward Highsmith Jr.; Single Nucleotide Polymorphisms: Testing DNA Variation for Disease Association; Ulrich Broeckel and Martin J. Hessner; Microarray Approaches to Gene Expression Analysis; David Neil Hayes and Matthew Meyerson; Methods for Analysis of DNA Methylation; Alexander Dobrovric; Part IV. Other Clinical Diagnostic Technologies; Flow Cytometry; Joseph A. DiGiuseppe; Medical Cytogenetics; Martha B. Keagle; Fluorescence In Situ Hybridization: A Major Milestone in Luminous Cytogenetics


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Product Details
  • ISBN-13: 9781592599288
  • Publisher: Humana Press Inc.
  • Publisher Imprint: Humana Press Inc.
  • Edition: Revised edition
  • Sub Title: For the Clinical Laboratorian
  • ISBN-10: 1592599281
  • Publisher Date: 01 Jan 2005
  • Binding: Digital (delivered electronically)
  • Language: English


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