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monde du microARN-377 et de la sclérose en plaques

monde du microARN-377 et de la sclérose en plaques

          
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About the Book

L'une des études les plus récentes en génétique a examiné le rôle des microARN en tant que marqueurs biologiques pour le diagnostic de la sclérose en plaques. Il existe des petites et des grandes plaques dans la substance blanche du cerveau et de la moelle épinière. miR377-3p, anciennement appelé has-miR-377-3p, est situé dans la région chromosomique 32q14 et se trouve dans le gène SOD. La SOD (dismutase superoxyde dismutase) est un gène présent dans la région chromosomique 22q21 et la protéine codée par ce gène est l'enzyme superoxyde dismutase. Le but de cette étude était d'étudier l'expression de miR-377 chez des patients atteints de SEPR (sclérose en plaques récurrente) et chez des personnes en bonne santé n'ayant pas d'antécédents de maladie auto-immune ou inflammatoire. Selon les résultats, l'expression du miR-377-3p était plus élevée chez les patients que chez les sujets sains (P = 0,036) et la sensibilité et la valeur diagnostique du miRNA étaient égales à 0,80 ASC. Les résultats étaient conformes aux études précédentes et le miR-377-3p peut être utilisé comme marque pour diagnostiquer la sclérose en plaques.


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Product Details
  • ISBN-13: 9786200950901
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Sciencia Scripts
  • Height: 229 mm
  • No of Pages: 76
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6200950903
  • Publisher Date: 08 May 2020
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 123 gr


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