The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

Table of Contents:
Table of Contents Preface List of Contributors Section A: Scientific Foundations A1: Classification and Clinical Features of Movement Disorders A2: Animal Models and the Science of Movement Disorders A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders A4: Genetics of Spontaneous Mutations in Mice A5: Assessment of Movement Disorders in Rodents A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals A7: Behavior in Drosophila: Analysis and Control A8: Use of C. elegans to Model Human Movement Disorders Section B: Parkinson Disease B1: The Phenotypic Spectrum of Parkinson Disease B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates B3: From Man to Mouse: The MPTP Model of Parkinson Disease B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease B5: Drosophila Models of Parkinson Disease B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease B8: Motor Complications in Primate Models of Parkinson Disease B9: C. elegans Models of Parkinson Disease Section C: Dystonia C1: Clinical Features and Classification of the Human Dystonias C2: The Genetically Dystonic Rat C3: Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm C4: Mouse Models of Dystonia C5: The Owl Monkey Model of Focal Dystonia C6: DYT1 Transgenic Mouse C7: The hph-1 Mouse Section D: Huntington Disease D1: Clinical and Pathological Characteristics of Huntington Disease D2: Transgenic Rodent Models of Huntington Disease D3: Knock-in and Knock-out Models of Huntington Disease D4: Drosophila Models of Huntington Disease Section E: Tremor Disorders E1: Neurophysiologic Characterization of Tremor E2: Essential Tremor E3: Harmaline Tremor E4: GABAA Receptor a1 Subunit Knockout Mice: A Novel Model of Essential Tremor E5: Production and Physiological Study of Holmes Tremor in Monkeys E6: The Campus Syndrome in Pietrain Pig Section F: Myoclonus F1: Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus F2: Post-Hypoxic Myoclonus in Rodents F3: Baboon Model of Myoclonus Section G: Tic Disorders G1: Tourette Syndrome G2: Animal Models of Tourette Syndrome Section H: Paroxysmal Movement Disorders H1: Paroxysmal Dyskinesias in Humans H2: The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia H3: Mouse Models of Hyperekplexia H4: Bovine Hyperekplexia H5: Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways Section I: Progressive Supranuclear Palsy and Corticobasal Ganglionic Degeneration I1: Progressive Supranuclear Palsy and Corticobasal Degeneration I2: Genetic Susceptibility and Animal Modeling of PSP I3: Rodent Models of Tauopathies Section J: Multiple System Atrophy J1: Clinical Spectrum and Pathological Features of Multiple System Atrophy J2: Double-Lesion Animal Models of Multiple System Atrophy J3: A Mouse Model for Multiple System Atrophy Section K: Ataxias K1: Clinical and Pathological Features of Hereditary Ataxias K2: Acquired Ataxias K3: Animal Models of Spinocerebellar Ataxia Type 1 (SCA1) K4: Spinocerebellar Ataxia Type 2 (SCA2) K5: SCA7 Mouse Models K6: Animal Models of Friedreich Ataxia K7: Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders Section L: Spasticity L1: Spasticity L2: Hereditary Spastic Paraplegia: Clinical Features and Animal Models L3: The Spastic Rat with Sacral Spinal Cord Injury L4: Rat Spinal Cord Contusion Model of Spasticity Section M: Drug-induced Movement Disorders M1: Drug-Induced Movement Disorders M2: Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates M3: Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents M4: Animal Models of Drug-Induced Akathisia Section N: Restless legs Syndrome N1: Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement Index