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Neocarzinostatin: The Past, Present, and Future of Anticancer Drug(English)

Neocarzinostatin: The Past, Present, and Future of Anticancer Drug(English)

          
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About the Book

Neocarzinostatin, discovered in 1964, is a naturally occurring antitumour agent. With its unique enediyne chromophore, it was the first protein antibiotic ever used clinically and has become the prototypical anticancer agent in its class. This volume presents a comprehensive treatment of the past, present and future development of neocarzinostatin, from the earliest findings to the most up-to-date research. Included are descriptions of the general characteristics of neocarzinostatin, the amino acid sequence and chemical structure of the protein portion and the chromophore, two-dimensional NMR study, X-ray crystallography, the mode of action at the molecular level, and the immunopotentiating effect. Clinical effects and side effects are also discussed, as is development of a polymer conjugate for the polymer drug SMANCS and its clinical application.

Table of Contents:
Chemical Structure of the Apoprotein of Neocarzinostatin.- Neocarzinostatin Chromophore: Structure and Mechanism of DNA Cleavage.- Synthesis and Chemistry of Nine-Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics.- Solution Structure of Neocarzinostatin Determined by Homonuclear Two-Dimensional Nuclear Magnetic Resonance.- Three-Dimensional Structure of Neocarzinostatin.- The Biochemical Mechanisms Involved in the Biological Effects Induced by Neocarzinostatin (NCS) and the NCS Chromophore.- Activation of Neocarzinostatin by NADPH Cytochrome P-450 Reductase: Proposal of an Ultimate Mode of Action in Cells Involving Oxygen Free Radicals.- Immunomodulating Antitumor Mechanisms of SMANCS.- Host-Mediated Antitumor Activity Induced by Neocarzinostatin and Its Polymer-Conjugated Derivative in Tumor-Bearing Mice.- Pharmacological Uniqueness and Clinical Effects of Neocarzinostatin.- Metamorphosis of Neocarzinostatin to SMANCS: Chemistry, Biology, Pharmacology, and Clinical Effect of the First Prototype Anticancer Polymer Therapeutic.- Supplementary Materials: Publications on Neocarzinostatin or Related Subjects, in English, 1960-1981.


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Product Details
  • ISBN-13: 9784431701873
  • Publisher: Springer Verlag, Japan
  • Publisher Imprint: Springer Verlag, Japan
  • Language: English
  • Returnable: N
  • Sub Title: The Past, Present, and Future of Anticancer Drug
  • ISBN-10: 4431701877
  • Publisher Date: 31 Dec 1996
  • Binding: Hardback
  • No of Pages: 287
  • Series Title: English
  • Weight: 760 gr


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