Herbert Henri Jasper is a scientist whose research activities have initiated and encompassed many of the major themes of neuroscience. He has pioneered in single unit recording, chronic neuronal studies, neurochemistry, electroencephalography, and many other disciplines. His students now hold important positions in universities and hospitals around the world. From July 21 to 23, 1986, a symposium entitled Neurotransmitters and Cortical Function: From Molecules to Mind was held in Montreal to honor Professor Jasper and to continue his pioneering efforts. The following chapters originated in that meeting. They summarize the current v vi PREFACE status of our knowledge in some of the fields influenced by Professor Jasper. They share a focus on neurotransmitters in cortical function, where we presume higher mental events originate. Professor Jasper has made contributions to the understanding of three different classes of neuro­ transmitters: GABA, acetylcholine, and catecholamines. It is an interest in trying to link neu­ rochemical events to some aspects of complex brain function and behavior that has characterized his work, and it is this philosophy that led to the present symposium to honor him. We dedicate this volume to Professor Jasper and the integrative approach that he has fostered. The Editors Montreal Contents 1. H. H. Jasper, Neuroscientist of Our Century .......................... .

Table of Contents:
1. H. H. Jasper, Neuroscientist of Our Century.- 2. H. H. Jasper: Modern Concepts of Epilepsy.- 3. Functional Organization of Glutamatergic Synapses.- 4. Anatomy of Putative Glutamatergic Neurons.- 5. Molecular and Functional Characterization of a Brain Neuronal Membrane Glutamate-Binding Protein.- 6. L-Glutamate and Its Agonists: Synaptic and Ionic Mechanisms in the Central Nervous System.- 7. Effects of Excitatory Amino Acid Agonists and Antagonists on in Vitro Motoneurons.- 8. Blockade of Excitatory Amino Acid Transmitters and Epilepsy.- 9. GABA Neurons and Their Cotransmitters in the Primate Cerebral Cortex.- 10. Rate-Limiting Steps in the Synthesis of GABA and Glutamate.- 11. GABAergic Processes in the Central Visual System.- 12. GABAergic Mechanisms and Epileptic Discharges.- 13. Modulatory Sites Associated with the GABA Receptor-Ionophore Complex and the Development of New, Potentially Specific Therapeutic Agents.- 14. Acetylcholine as Transmitter in the Cerebral Cortex.- 15. Central Cholinergic Pathways: Neuroanatomy and Some Behavioral Implications.- 16. The Synthesis and Storage of Acetylcholine in Mammalian Cholinergic Nerve Terminals.- 17. Modulation of Neuronal Excitability by Acetylcholine.- 18. Postsynaptic Actions of Acetylcholine in the Mammalian Brain in Vitro.- 19. Cholinergic Modulation of Neuronal Excitability in Cat Somatosensory Cortex.- 20. Evidence That Acetylcholine Acts in Vivo in Layer V Pyramidal Cells of Cats via cGMP and a cGMP-Dependent Protein Kinase to Produce a Decrease in an Outward Current.- 21. Structural Basis of Cortical Monoamine Function.- 22. The Heterogeneity of the Catecholamine Innervation of Cerebral Cortex: Biochemical and Electrophysiological Studies.- 23. Cerebrocortical Neurons Containing DARPP-32, a Dopamine- and Adenosine 3?: 5? Monophosphate-Regulated Phosphoprotein.- 24. Synaptic Regulation of Locus Coeruleus Neuronal Activity.- 25. Cortical Monoamines and Injured Brain.- 26. Behavioral and Other Actions of Adenosine in the Central Nervous System.- 27. Adenosine: A Molecule for Synaptic Homeostasis? Evolution of Current Concepts on the Physiological and Pathophysiological Roles of Adenosine in the Brain.- 28. Formation and Actions of Adenosine in the Rat Hippocampus, with Special Reference to the Interactions with Classical Transmitters.- 29. Mediation of Nonclassical Postsynaptic Responses by Cyclic Nucleotides.- 30. Modulation of Synaptically Evoked Neuronal Calcium Fluxes by Adenosine.- 31. Electrophysiological Analysis of Effects of Exogenous and Endogenous Adenosine in Hippocampal Slices.- 32. Electrophysiology of a Peptidergic Neuron: The Hypothalamic Magnocellular Neurosecretory Cell.- 33. Neuronal and Endocrine Peptides: Diversity and Gene Expression.- 34. Mechanisms of Neuropeptide Precursor Processing: Implications for Neuropharmacology.- 35. Autoradiographic Localization of Brain Peptide Receptors at the Electron Microscopic Level.- 36. Neuropeptide Receptors in the Brain: Possible Relevance to Function.- 37. Increases in Potassium Conductance: Common Mechanisms of Opiate Action in Neurons of the Central Nervous System.- 38. Molecular Controls and Communication in Cerebral Cortex:An Overview.- 39. Addendum of Appreciation.- Contributors.