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Next Generation Linkage Analysis: Special Topic Issue: Human Heredity 2011, Vol. 72, No. 4

Next Generation Linkage Analysis: Special Topic Issue: Human Heredity 2011, Vol. 72, No. 4

          
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About the Book

With the advent of affordable high-throughput genetic sequence, the human genetics community is returning to a focus on family data. Sequencing family members can facilitate data cleaning by identifying non-Mendelizing putative variants. It can provide a powerful mechanism for discerning the relevant sequence variants, by focusing on those segregating with the phenotype of interest. By the same token, sequencing holds out the possibility of capitalizing on earlier gene localization findings based on analyses of family data - findings that have provided numerous tantalizing loci for a wide range of complex phenotypes, but to date have resulted in relatively little definitive identifications of specific causal genes. This special issue of ‘Human Heredity’ is intended to showcase some of the advances in the statistical and computational technologies now available for linkage analysis. As the field returns to an appreciation of the power of linkage analysis, the collection of papers will convey the flavor of what is now possible. Human geneticists and scientists involved in gene mapping studies will gather information on new methods and computer programs available for linkage analysis to parallel sequencing experiments.

Table of Contents:
Next-Generation Linkage Analysis: Vieland, V.J.; Devoto, M.; Linkage Analysis in the Next-Generation Sequencing Era: Bailey-Wilson, J.E.; Wilson, A.F.; Some Capabilities for Model-Based and Model-Free Linkage Analysis using the Program Package S.A.G.E. (Statistical Analysis for Genetic Epidemiology): Schnell, A.H.; Sun, X.; Igo Jr., R.P.; Elston, R.C.; Computer Simulation is an Undervalued Tool for Genetic Analysis: A Historical View and Presentation of SHIMSHON - A Web-Based Genetic Simulation Package: Greenberg, D.A.; Detecting Pleiotropy and Epistasis Using Variance Components Linkage Analysis in jPAP: Hasstedt, S.J.; Thomas, A.; Using Parametric Multipoint Lods and Mods for Linkage Analysis Requires a Shift in Statistical Thinking: Hodge, S.E.; Baskurt, Z.; Strug, L.J.; KELVIN: A Software Package for Rigorous Measurement of Statistical Evidence in Human Genetics: Vieland, V.J.; Huang, Y.; Seok, S.-C.; Burian, J.; Catalyurek, U.; O'Connell, J.; Segre, A.; Valentine-Cooper, W.; Estimation and Visualization of Identity-by-Descent within Pedigrees Simplifies Interpretation of Complex Trait Analysis: Marchani, E.E.; Wijsman E.M.


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Product Details
  • ISBN-13: 9783805599412
  • Publisher: S Karger Ag
  • Publisher Imprint: S Karger AG
  • Language: English
  • Returnable: N
  • Sub Title: Special Topic Issue: Human Heredity 2011, Vol. 72, No. 4
  • ISBN-10: 3805599412
  • Publisher Date: 12 Jan 2012
  • Binding: Paperback
  • No of Pages: 76
  • Series Title: English
  • Weight: 282 gr


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