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The Pathogenesis of Salvarsan Fatalities: (English)

The Pathogenesis of Salvarsan Fatalities: (English)

          
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About the Book

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1913. Excerpt: ... "'Arsenoxide' is readily formed by exposing the alkaline solution to the air, and in my personal opinion this 'Arsenoxide' is the chief cause of the serious reactions so often complained of. In support of this statement I am relying upon the experiences which were extensively described and related in the first experiments and observations with arsenophenylglycin disturbances occurred in the beginning; one case resulted fatally. The disagreeable manifestations were probably caused by my first method in preserving the arsenophenylglycin in which at least ten per cent, of cases of serious disturbances occurred in the beginning; glycin in ordinary stoppered bottles instead of, as now, in vacuo." "It is my belief," says Prof. Ehrlich, further, "that the interference with the renal function which you presume exists, is occasioned by the retention of salvarsan in the organism or blood, which favors the formation of the more dangerous arsenoxide. At least it seems almost proven that certain easily oxydizable substances which under ordinary conditions do not color animals, cause a distinct bluish coloration of the body of animals which receive too large a dose of the substance which consequently causes an inhibition of proper elimination of the drug. There occurred then a biological oxydation, and this I prefer to accept in explanation of the unhappy effects following salvarsan." 3. "The Arsenoxide can be still further oxidized, to phenylarsin acid. I believe, however, that this is but rarely the case; at any rate such an extensize oxydation cannot be drawn upon to furnish an explanation of death since the p-Oxymetamidophenylarsinacid is much less toxic than salvarsan and in the employed dosage must be considered as without danger." Salvarsan which has undergone d...


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Product Details
  • ISBN-13: 9781151332059
  • Publisher: General Books
  • Publisher Imprint: General Books
  • Height: 246 mm
  • No of Pages: 38
  • Series Title: English
  • Weight: 86 gr
  • ISBN-10: 1151332054
  • Publisher Date: 01 Feb 2012
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 2 mm
  • Width: 189 mm


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