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Perfusion de Cisplatine Hypotonique Dans Le Foie Isolé

Perfusion de Cisplatine Hypotonique Dans Le Foie Isolé

          
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About the Book

La résection est le seul traitement curatif des tumeurs du foie, mais seul un tiers des patients est éligible à la chirurgie. La perfusion de chimiothérapie dans le foie isolé de la circulation générale permettrait de délivrer de fortes doses de drogue en l'absence de toxicité systémique. Le cisplatine a montré une meilleure pénétration intracellulaire et une forte activité en milieu hypotonique. Cette étude expérimentale sur 10 porcs a consisté en une perfusion de cisplatine hypotonique sur foie isolé, grâce à un circuit ouvert entrant par la veine porte et sortant par la veine cave inférieure. En 30 minutes, 3 L de cisplatine en milieu hypotonique ont été perfusés. La tolérance per-opératoire a été bonne grâce à un clampage aortique intermittent. Les quantités de cisplatine dosées dans la circulation générale étaient minimes, confirmant l'efficacité de l'exclusion. Il n'y a eu aucune toxicité systémique. La toxicité histologique hépatique existait aux concentrations de 100 et 75 mg/L, mais pas à 50 mg/L. L'exposition in vitro à des cellules cancéreuses humaines hyper-résistantes a montré une cytotoxicité de 90%, signe d'une forte activité antitumorale in vitro.


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Product Details
  • ISBN-13: 9783838178943
  • Publisher: Academiques
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 3838178947
  • Publisher Date: 28 Feb 2018
  • Height: 229 mm
  • No of Pages: 80
  • Series Title: Omn.Pres.Franc.
  • Weight: 131 gr


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