Plasmonic Sensors and their Applications A practically-focused reference and guide on the use of plasmonic sensing as a faster and cheaper alternative to conventional sensing platforms Plasmons, the collective oscillations of electrons occurring at the interface between any two materials, are sensitive to changes in dielectric properties near metal surfaces. Plasmonic sensors enable the real-time study of unique surface properties by monitoring the effect of the material interaction at the sensor surface. Plasmonic sensing techniques offer fast, label-free analysis, and hold advantages over labelling techniques such as ELISA (enzyme-linked immunosorbent assay). Plasmonic Sensors and their Applications examines the development and use of highly sensitive and selective plasmonic sensing platforms in chemistry, biotechnology, and medicine. Contributions by an international panel of experts provide timely and in-depth coverage of both real-world applications and academic research in the dynamic field. The authors describe advances in nanotechnology, polymer chemistry, and biomedicine, explore new and emerging applications of plasmonic sensing, discuss future trends and potential research directions, and more. This authoritative volume: Demonstrates why plasmonic sensing is a profitable method for easy and label-free analysis in real-time Covers a variety of applications of plasmonic sensors, such as disease diagnostics, vitamin detection, and detection of chemical and biological warfare agents Includes a brief introduction to the history and development of plasmonic sensors Provides concise theory and background for every application covered in the text Plasmonic Sensors and their Applications is an invaluable resource for analytical chemists, biochemists, biotechnologists, protein and surface chemists, and advanced students of biotechnology.

Table of Contents:
Preface xi 1 Deciphering Plasmonic Modality to Address Challenges in Disease Diagnostics 1 Esma Derin, Özgecan Erdem, and Fatih Inci 1.1 Introduction 1 1.2 Surface Plasmon Polaritons 2 1.2.1 Excitation of the SPP 3 1.3 Surface Plasmon Resonance (SPR) 4 1.4 Localized Surface Plasmon Resonance (LPSR) 5 1.5 Raman Spectroscopy and SERS 7 1.6 Whispering Gallery Mode (WGM) 8 1.7 Fiber Cables Sensors 9 1.8 New Trends in Plasmonic Sensors for the Applications in Disease Diagnosis 11 1.8.1 Mobile Phone-Integrated Platforms 11 1.8.2 Smart Material Integration 12 1.8.3 Naked-Eye Detection 16 1.9 Outcomes and Conclusion 18 References 19 2 Nanosensors Based on Localized Surface Plasmon Resonance 23 Deniz Umut Yildirim, Amir Ghobadi, and Ekmel Ozbay 2.1 Historical and Theoretical Background 23 2.2 Fabrication of Metal Nanostructures 29 2.3 Improving Detection Limit of LSPR Sensors 31 2.4 Integration of LSPR with Other Molecular Identification Techniques 34 2.4.1 Metal-Enhanced Fluorescence 34 2.4.2 Surface-Enhanced Raman Spectroscopy 37 2.4.3 Matrix-Assisted Laser Desorption Ionization Mass Spectroscopy 39 2.5 Practical Issues 39 2.6 Conclusions and Future Prospects 43 References 44 3 Highly Sensitive and Selective Plasmonic Sensing Platforms 55 Yeşeren Saylan and Adil Denizli 3.1 Introduction 55 3.2 What Is Highly Sensitive (Ultrasensitive)? 56 3.3 Plasmonic Sensing Platforms 56 3.4 Recent Applications 57 3.4.1 Medical Applications 57 3.4.2 Environmental Applications 61 3.5 Conclusion Remarks 67 References 67 4 Plasmonic Sensors for Detection of Chemical and Biological Warfare Agents 71 Semra Akgönüllü, Yeşeren Saylan, Nilay Bereli, Deniz Türkmen, Handan Yavuz, and Adil Denizli 4.1 Introduction 71 4.2 Sensors 72 4.2.1 Plasmonic-based Sensors 72 4.3 Biological Warfare Agents 72 4.3.1 Detection of Biological Warfare Agents 73 4.4 Chemical Warfare Agents 79 4.4.1 Detection of Chemical Warfare Agents 79 4.5 Conclusion and Future Perspective 81 References 82 5 A Plasmonic Sensing Platform Based on Molecularly Imprinted Polymers for Medical Applications 87 Neslihan Idil, Monireh Bakhshpour, Sevgi Aslıyüce, Adil Denizli, and Bo Mattiasson 5.1 Introduction 87 5.2 Molecular Imprinting Technology 88 5.3 Plasmonic Sensing 89 5.4 Medical Applications 91 5.4.1 Drug Detection Via MIP-based SPR Sensor 91 5.4.2 Hormone Detection Via MIP-based SPR Sensor 94 5.4.3 Microorganism and Virus Detection Via MIP-based SPR Sensor 95 5.4.4 Antibody Detection Via MIP-based SPR Sensor 96 5.4.5 Nucleic Acid Detection Via MIP-based SPR Sensor 97 5.4.6 Biomarker Detection Via MIP-based SPR Sensor 97 5.5 Conclusion 97 References 100 6 Magnetoplasmonic Nanosensors 103 Recep Üzek, Esma Sari, and Arben Merkoçi 6.1 Introduction 103 6.2 Synthesis 104 6.2.1 Core–Shell or Core–Satellite 105 6.2.2 Heterodimers 107 6.2.3 Multicomponent Doped Hybrids 108 6.3 Biosensing Applications 109 6.3.1 Protein 109 6.3.2 Pathogens 111 6.3.3 DNA 112 6.4 Conclusion 113 Acknowledgments 114 References 114 7 Plasmonic Sensors for Vitamin Detection 121 Duygu Çimen and Nilay Bereli 7.1 Introduction 121 7.1.1 Vitamins 121 7.2 Plasmonic Sensors 122 7.2.1 Surface Plasmon Resonance Sensors 123 7.2.2 Localized Surface Plasmon Resonance Sensors 124 7.2.3 Colorimetric Sensors 125 7.3 Vitamin Applications of Plasmonic Sensors 125 7.4 Conclusions and Prospects 133 References 133 8 Proteomic Applications of Plasmonic Sensors 137 Duygu Çimen, Merve Asena Özbek, Nilay Bereli, and Adil Denizli 8.1 Introduction 137 8.2 Plasmonic Sensors 139 8.2.1 Surface Plasmon Resonance Sensors 140 8.2.2 Localized Surface Plasmon Resonance 140 8.2.3 Colorimetric Sensors 142 8.3 Proteome Applications with Plasmonic Sensors 142 8.3.1 Food Applications 142 8.3.2 Biomedical Applications 145 8.3.3 Agricultural Applications 151 8.3.4 Oncology Applications 152 8.4 Conclusions and Prospects 154 References 154 9 Cancer Cell Recognition via Sensors System 157 Monireh Bakhshpour, Melek Özsevgiç, Ayşe Kevser Pişkin, and Adil Denizli 9.1 Introduction 157 9.2 Sensors Systems in Cancer Cell Detection 158 9.3 Cancer Cells 158 9.3.1 Prostate Cancer 159 9.3.2 Liver Cancer 160 9.3.3 Breast Cancer 160 9.3.4 Lung Cancer 164 9.3.5 Ovarian Cancer 164 9.3.6 Other Cells 165 9.4 Conclusion 168 References 168 10 Ultrasensitive Sensors Based on Plasmonic Nanoparticles 171 Ilgım Göktürk, Fatma Denizli, Erdoğan Özgür, and Fatma Yılmaz 10.1 Introduction 171 10.2 SPR and LSPR 173 10.3 SERS 176 10.4 Colorimetric Sensing 178 10.5 Luminescence Applications 179 10.6 Conclusion 180 References 181 11 Surface-Enhanced Raman Scattering Sensors for Chemical/Biological Sensing 189 Huma Shaikh, Zaib un Nisa Mughal, Saeed Memon, and Shahabuddin Memon 11.1 Introduction 189 11.2 Direct Method 192 11.3 Indirect Method 193 11.4 SERS-based Chemical Sensors (Chemosensors) 193 11.5 Absolute Intensity-based Method 195 11.6 Wavenumber Shift-based Method 195 11.7 Ratiometric Method 196 11.8 SERS-based Biological Sensors (Biosensors) 197 11.9 Conclusion 202 References 202 12 Carbon Nanomaterials as Plasmonic Sensors in Biotechnological and Biomedical Applications 209 Tahira Qureshi, Kemal Ҫetin, and Adil Denizli 12.1 Introduction 209 12.1.1 Graphene 210 12.1.2 Carbon Nanotubes 210 12.2 Biomedical and Biotechnological Applications of Carbon Nanomaterials as Plasmonic Sensors 211 12.2.1 Graphene-based Plasmonic Sensors 211 12.2.2 Carbon Nanotube-based Plasmonic Sensors 214 12.3 Final Statement and Further Outlook 215 References 217 13 Surface Plasmon Resonance Sensors Based on Molecularly Imprinted Polymers 221 Cem Esen and Sergey A. Piletsky 13.1 Introduction 221 13.1.1 Surface Plasmon Resonance 221 13.1.2 Molecularly Imprinted Polymers 222 13.2 MIP Based SPR Sensors 222 13.2.1 MIP Film Based SPR Sensors 223 13.2.2 Molecularly Imprinted Polymer Nanoparticles Based SPR Sensors 225 13.3 Conclusions and Future Prospects 229 References 230 Index 237