Provides information on provocative challenges and offers step-by-step methods of performing specific procedures on a number of organ systems in the body. The mechanisms, diagnoses and treatement regimens for challenged normal and abnormal physiological systems are delineated. The work is intended for allergists and clinical immunologists, pulmonogists, dermatologists, ophthalmologists, pharmacologits, family practice physicians, and graduate-level and medical school students in these disciplines.

Table of Contents:
Allergenic Extracts, John W. Yunginger Standardization of Allergens, Jean Bousquet and Fran¸la;ois-B. Michel Use of the Skin Blister Model and Intradermal Testing to Explore the Pathogenesis and Pharmacological Control of Cutaneous Allergic Inflammation, William A. Massey and Lawrence M. Lichtenstein Experimental Provoked Viral Respiratory Infections in Human Adult Volunteers, Philip Fireman The Effects of Respiratory Infections on Airway Function, Nizar N. Jarjour, Robert F. Lemanske, Jr., Elliot C. Dick, William J. Calhoun, and William W. Busse Air Pollutants as a Provocative Challenge in Humans, Henry Gong, Jr. Deposition and Fate of Inhaled Pharmacological Aerosols, Joseph D. Brain and James D. Blanchard Methodologies of Aerosol Delivery, Richard R. Rosenthal Bronchial Challenge Testing: In Vivo&emdash;In Vitro Correlations, Carol A. Hirshman The Use of Nonisotonic Aerosols for Evaluating Bronchial Hyperresponsiveness, Sandra D. Anderson, Christine M. Smith, Leanne T. Rodwell, Jacqueline I. du Toit, Josef Riedler, and Colin F. Robertson Inhalation Challenges with Lipid Mediators (Leukotrienes, Prostaglandins, and PAF-Acether) and Adenosine, Jonathan P. Arm and Tak H. Lee Airway Challenges with Inhaled Constrictor Mediators, Paul M. O'Byrne and Noe Zamel Allergen Inhalation Challenges, Sheldon L. Spector Environmental Challenges to Animal Allergens, Robert A. Wood and Peyton A. Eggleston Genetic Aspects of Asthma and Bronchial Hyperresponsiveness, Robert G. Townley, Russell J. Hopp, A. K. Bewtra, and Nicki M. Nair Protective Effect of Inhaled Loop Diuretics on Experimentally Induced Bronchoconstriction, S. Bianco, M. G. Pieroni, R. M. Refini, P. Sestini, M. Robuschi, and A. Vaghi Provocative Challenge by Exercise or Hyperventilation, J. F. Souhrada and M. Souhrada Inhalation Bronchoprovocation in Children, Paul V. Williams and Gail Shapiro Use of Inhalation Bronchial Challenge for Occupational Diseases, David J. Hendrick and John E. Salvaggio Measurement and Significance of the Bronchodilator Response: Bronchodilation and Inhibition of Bronchoprovocation, Donald P. Tashkin Airway Hyperresponsiveness in Irreversible Chronic Obstructive Pulmonary Disease, Donald P. Tashkin, Murray D. Altose, John E. Connett, Richard E. Kanner, Wondra Wong Lee, Robert Wise, and the Lung Health Study Research Group Aspirin, Sulfur Dioxide/Sulfite, and Other Chemical Sensitivities and Challenges in Asthmatic Patients, David A. Mathison, Ronald A. Simon, and Donald D. Stevenson Diagnosing Food Allergy, Hugh A. Sampson Nasal Provocative Testing, William R. Solomon Conjunctival Challenge, Michael B. Raizman Clinical Application of Immediate Skin Testing, Harold S. Nelson Delayed Hypersensitivity, Cell-Mediated Immunity, and Anergy, Charles H. Kirkpatrick Provocative Tests in Dermatology, Antti I. Lauerma and Howard I. Maibach Drug Desensitization, John A. Anderson