Psychoneuroimmunology is the study of interactions between the brain and the immune system. This book provides a clearly written, extensively referenced summary of the behavioral, neural and endocrine regulation of immune responses and of the effects of immune system activity on neural and endocrine functions and behavior. It goes beyond previous editions, not only in the amount of basic research that is covered, but by the inclusion of several chapters that address the clinical implications of psychoneuroimmunology for a variety of disease processes. The underlying premise, evidenced by content of this book, is that the brain and immune system represent a single, integrated system of defense. It features: state-of-the-art reviews by established investigative teams; integrative, definitive, and multidisciplinary reviews; clinical and basic sciences coverage; new directions for clinical and basic research; and, extensive references and indexing.

Table of Contents:
H.O. Besedovsky and A. Del Rey, Cytokines as Mediators of Central and Peripheral Immune-Neuroendocrine Interactions. N. Cohen and K.S. Kinney, Exploring the Phylogenetic History of Neural-Immune System Interactions. D.L. Bellinger, D. Lorton, C. Lubahn, and D.L. Felten, Innervation of Lymphoid Organs--Association of Nerves with Cells of the Immune System and their Implications in Disease. D. Lorton, C. Lubahn, and D. Bellinger, Introduction to Biological Signaling in Psychoneuroimmunology. V.M. Sanders, D.J. Kasprowicz, A.P. Kohm, and M.A. Swanson, Neurotransmitter Receptors on Lymphocytes and Other Lymphoid Cells. K.S. Madden, Catecholamines, Sympathetic Nerves and Immunity. J.P. McGillis, S. Fernandez, and M.A. Knopf, Regulation of Immune and Inflammatory Reactions in Local Microenvironments by Sensory Neuropeptides. S.L. Carlson, Neural Influences on Cell Adhesion Molecules and Lymphocyte Trafficking. D.L. Bellinger, K.S. Madden, D. Lorton, S. Thyagarajan, and D.L. Felten, Age-Related Alterations in Neural-Immune Interactions and Neural Strategies in Immunosenescence. C.S. Boomershine, T. Wang, and B.S. Zwilling, Neuroendocrine Regulation of Macrophage and Neutrophil Function. F.S. Dhabhar and B.S. McEwen, Bidirectional Effects of Stress and Glucocorticoid Hormones on Immune Function: Possible Explanations for Paradoxical Observations. H.D. Venters, R. Dantzer, G.G. Freund, S.R. Broussard, and K.W. Kelley, Growth Hormone and Insulin-Like Growth Factor as Cytokines in the Immune System. B. Marchetti, M.C. Morale, F. Gallo, E. Lomeo, N. Testa, C. Tirolo, S. Caniglia, and G. Garozzo, The Hypothalamo-Pituitary-Gonadal Axis and the Immune System. F. Eriksson, A. Kavelaars, and C.J. Heijnen, Preproenkephalin: An Unappreciated Neuro-Immune Communicator. D.J.J. Carr and R.J. Weber, Opioidergic Modulation of the Immune System. T.W. Klein, C. Newton, E. Snella, and H. Friedman, Marijuana, the Cannabinoid System, and Immunomodulation. G.J.M. Maestroni, Melatonin and Immune Function. R.B. Sothern and B. Roitman-Johnson, Biological Rhythms and Immune Function. W.A. Banks, Cytokines, CVSs, and the Blood-Brain Barrier. S. Reichlin, Sectretion of Immunomodulatory Mediators from the Brain: An Alternative Pathway of Neuroimmunomodulation. T. Hori, T. Katafuchi, and T. Oka, Central Cytokines: Effects on Peripheral Immunity, Inflammation and Nociception. J.E. Merrill, Production and Influence of Inflammatory Cytokines in Diseases of the Adult Central Nervous System. S.F. Maier, L.R. Watkins, and D.M. Nance, Multiple Routes of Action of Interleukin-1 on the Nervous System. U. Hanisch, Effects of Interleukin-2 and Interferons on the Nervous System. C. Rivier, The Hypothalamo-Pituitary-Adrenal Axis Response to Immune Signals. A.J. Dunn, Effects of Cytokines and Infections on Brain Neurochemistry. J.M. Krueger, J. Fang, and J.A. Majde, Sleep in Health and Disease. M.J. Kluger, W. Kozak, and K.P. Mayfield, Fever and Immunity. R. Dantzer, R. Bluthe, N. Castanon, N. Chauvet, L. Capuron, G. Goodall, K.W. Kelley, J. Konsman, S. Laye, P. Parnet, and F. Pousset, Cytokine Effects on Behavior. R. Ader and N. Cohen, Conditioning and Immunity. C.J. Barnard and J.M. Behnke, From Psychoneuroimmunology to Ecological Immunology: Life History Strategies and Immunity Trade-offs. A.N. Taylor, F. Chiappelli, and R. Yirmiya, Fetal Alcohol Syndrome and Immunity. J.M. Worlein and M.L. Laudenslager, Effects of Early Rearing Experiences and Social Interactions on Immune Function in Nonhuman Primates. S.C. Segerstom, M.E. Kemeny, and M.L. Laudenslager, Individual Difference Factors in Psychoneuroimmunology. H. Machelska, S.A. Mousa, and C. Stein, Pain and Immune Function. L. Hoffman-Goetz and B.K. Pedersen, Immune Responses to Acute Exercise: Hemodynamic, Hormonal, and Cytokine Influences. R. Zachariae, Hypnosis and Immunity. N.R.S. Hall, Alternative Medicine and the Immune System. J.M. Petitto, Behavioral Genetics and Immunity. M. Biondi, Effects of Stress on Immune Functions: An Overview. J.A. Moynihan and S.Y. Stevens, Mechanisms of Stress-Induced Modulation of Immunity in Animals. D.T. Lysle, Nitric Oxide and Neural-Immune Interaction. A.W. Kusnecov, A. Sved, and B.S. Rabin, Immunologic Effects of Acute Versus Chronic Stress in Animals. G. Sonnenfeld, G.R. Taylor, and K.S. Kinney, Acute and Chronic Effects of Space Flight on Immune Functions. R. Zellweger, M.G. Schwacha, and I.H. Chaudry, Immunologic Sequelae of Surgery and Trauma. B.N. Uchino, G.G. Berntson, J. Holt-Lunstad, and J.T. Cacioppo, Stress-Induced Autonomic and Immunologic Reactivity. D.L. Delahanty, A.L. Dougall, and A. Baum, Neuroendocrine and Immune Alterations Following Natural Disasters and Traumatic Stress. E. Tarkowski, Impact of Brain Injury on Immune Function. M.H. Rapaport and N. Muller, Immunological States Associated with Schizophrenia. M. Irwin, Depression and Immunity. M.P. Rogers and E.B. Brooks, Psychological Influences, Immune Function, and the Progression of Autoimmune Disease. R.L. Wilder and I.J. Elenkov, Ovarian and Sympathoadrenal Hormones, Pregnancy and Autoimmune Diseases. A. Prat and J.P. Antel, Neuroendocrine Influences on Autoimmune Disease: Multiple Sclerosis. S. Ligier and E.M. Sternberg, The Neuroendocrine System and Rheumatoid Arthritis: Focus on the Hypothalamo-Pituitary-Adrenal Axis. S.P. Raychaudhuri and E.M. Farber, Neuroendocrine Influences on the Pathogenesis of Psoriasis. R.H. Bonneau, D.A. Padgett, and J.F. Sheridan, Psychoneuroimmune Interactions in Infectious Disease: Studies in Animals. S. Cohen and G.E. Miller, Stress, Immunity, and Susceptibility to Upper Respiratory Infection. R. J. Shephard and P.N. Shek, Physical Activity and Upper Respiratory Infection. W.J. Kop and N. Cohen, Psychological Risk Factors and Immune System Involvement in Cardiovascular Disease. S. Ben-Eliyahu and G. Shakhar, The Impact of Stress, Catecholamines, and the Menstrual Cycle on NK Activity and Tumor Development: From in Vitro Studies to Biological Significance. J.M. Turner-Cobbs, S.E. Sephton, and D. Spiegel, Psychosocial Effects on Immune Function and Disease Progression in Cancer: Human Studies. S.W. Cole and M.E. Kemeny, Psychosocial Influences on the Progression of HIV Infection. P.T. Marucha, J.F. Sheridan, and D. Padgett, Stress and Wound Healing. T. Breivik and P.S. Thrane, Psychoneuroimmune Interactions in Periodontal Disease. F. Chiappelli, A. Abanomy, D. Hodgson, K.A. Mazey, D.V. Messadi, R.S. Mito, I. Nishimura, and I. Spigelman, Clinical, Experimental and Translational Psychoneuroimmunology Research Models in Oral Biology and Medicine. H. Weiner and A.R. Shapiro, Helicobacter pylori, Immune Function and Gastric Lesions. S. Hosseini, T. Sepulveda, J. Lee, and R.R. Watson, Alcoholism and Immune Function. G.F. Solomon and J.E. Morley, Psychoneuroimmunology and Aging. Author Index. Subject Index.