Home > Medicine & Health Science textbooks > Pre-clinical medicine: basic sciences > Physiology > The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)
The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)

The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist
X

About the Book

This dissertation, "The Role of Ca2 in Protection of Preconditioning and Ischaemia-induced Injury in the Rat Heart" by Wing-yi, Yan, 殷詠儀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: 2+ Abstract of the thesis entitled 'The Role of Ca in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart' submitted by Miss Wing Yi Yan for the Degree of Master of Philosophy at The University of Hong Kong in December, 2003 2+ 2+ There is evidence that an increase in cytosolic Ca ([Ca ]c) precedes 2+ myocardial injury during ischaemia, suggesting that [Ca ]c overload is a precipitating cause of myocardial injury. This suggestion was based on results obtained from correlative studies. On the other hand ischaemia preconditioning, 2+ which confers cardioprotection, induces a transient increase of [Ca ]c, which is believed to trigger the events that lead to cardioprotection against subsequent 2+ 2+ ischaemia insults. There is increasing evidence that mitochondrial Ca ([Ca ]m) may also be responsible for cardiac injury and protection. The purpose of the present study 2+ 2+ was to test the hypothesis that an increase in intracellular Ca ([Ca ]c and/or 2+ [Ca ]m) may be a precipitating cause of cardiac injury by a cause effect study. Secondly, the present study also attempted to test the hypothesis that a transient 2+ 2+ 2+ increase in intracellular Ca ([Ca ]c and/or [Ca ]m) may be responsible for 2+ cardioprotection of preconditioning. A cell permeable Ca chelator, BAPTA-AM was used. Both isolated myocyte and isolated perfused heart of rat were used. Two series iof experiments were conducted. Firstly, isolated ventricular myocytes were incubated with 2-deoxy-D-glucose (2-DOG) and sodium hydrosulphite (Na S O), which 2 2 4 produces metabolic inhibition and anoxia (MI/A), both consequences of ischaemia, for 10 mins followed by perfusion with normal Krebs solution (reperfusion) for 10 2+ 2+ mins. [Ca ]c and [Ca ]m were measured by spectroflurometry and confocal microscopy, respectively. It was found that 10-min ischaemia caused a significant 2+ 2+ increase in [Ca ]c, but not [Ca ]m, during ischaemia and reperfusion. The viability of the myocytes as determined by trypan blue exclusion was also decreased following ischaemia/reperfusion. BAPTA-AM at 1, 2.5 and 25 M significantly and 2+ dose-dependently attenuated the increase in [Ca ]c during ischaemia. At 2.5 and 25 M, BAPTA-AM also significantly and dose-dependently decreased the elevation 2+ of [Ca ]c during reperfusion and increased viability of the myocytes. To further 2+ determine whether the Ca chelator also reduce myocardial injury induced by ischaemia/reperfusion when administered in vivo, BAPTA-AM at 0.5-2.5mg/kg was injected intravenously into the rats. One hr later, the heart was isolated and perfused with normal Krebs solution for 30 mins and subjected to ischaemia by ligation of left coronary artery for 30 mins followed by release of the ligation that produced reperfusion for 2 hrs. Ischaemia/reperfusion (I/R) induced myocardial infarct. BAPTA-AM at 1mg/kg, 1.5mg/kg and 2.5mg/kg significantly reduced the infarct size, iiindicating a cardioprotective effect, which is in agreement with the observation in the myocyte preparation. The study, which was based on cause effect relationship, has 2+ provided unequivocal evidence that [Ca ]c overload during ischaemia is a precipitating cause of myocardial injury. In the second series of experiment, myocytes were subjected to 3 cycles of 3 mins of MI/A interspersed with 3 mins of reperfusion - preconditioning with MI/A. Then they were subjec


Best Sellers


Product Details
  • ISBN-13: 9781374713789
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 74
  • Spine Width: 4 mm
  • Width: 216 mm
  • ISBN-10: 1374713783
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Series Title: English
  • Weight: 195 gr


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)
Open Dissertation Press -
The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

The Role of Ca2 in Protection of Preconditioning and Ischaemia-Induced Injury in the Rat Heart: (English)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA