Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Anaesthetics > Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)
Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)

Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist
X

About the Book

This dissertation, "Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes" by Haobo, Li, 李浩波, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Myocardial infarction remains the major perioperative complication that is associated with significant morbidity and mortality in patients with diabetes. Ischemic postconditioning (IPo) protects against myocardial ischemia reperfusion (IR) injury by activating signal transducer and activator of transcription 3(STAT3) in non-diabetes, but losses its effectiveness in diabetes, a pathology that is associated with reduction and/or malfunction of the cardioprotective molecule, adiponectin (APN). This thesis reports the results of three studies designed to determine the role of APN in IPo cardioprotection and its interplay with STAT3, and to identify the mechanism by which adiponectin interacts with cardiac STAT3 in the context of IPo in non-diabetic and diabetic subjects. In the first study, by applying different durations of ischemia and reperfusion in an in vivo ischemia reperfusion model, we explored whether or not hearts from diabetes is more susceptible to myocardial IR injury. We showed that hearts from diabetes, even at the early stage of the disease, is more vulnerable to myocardial IR injury than hearts from non-diabetic subjects. Furthermore, we showed that the severity of the post-ischemic myocardial injury of the diabetic hearts depended more on the duration of ischemia than that of reperfusion. In the second study, we investigated the mechanism underlies the cardioprotective effects of APN in attenuating diabetic cardiomyopathy, with a special focus on the role of APN's anti-oxidative effects in this process. We showed that APN, through concomitantly activating Nrf2 and Brg1, activated myocardial heme oxygenase-1(HO-1), which played critical roles in attenuating cardiac hypertrophy and cardiac dysfunction in streptozotocin-induced diabetic rats. Consistently, in cultured adult rat cardiomyocytes and cardiac H9C2 cells, administration of APN prevented high glucose(HG)-induced reduction of HO-1, Brg1, and nuclear Nrf2 protein expression and attenuated HG-induced elevations of lipid peroxidation, cardiomyocyte size, and apoptosis. However, these cardioprotective effects of APN were cancelled by either Nrf2, Brg1, or HO-1 inhibition/genes knockdown. Furthermore, we found that IPo increased post-ischemic cardiomyocyte-derived APN, activated mitochondrial STAT3 (mitoSTAT3), improved mitochondrial function, reduced myocardial oxidative stress, and ultimately attenuated myocardial IR injury, in wild-type but not in APN knockout (〖Adipo〗 DEGREES(-/-)) mice. IPo-induced protection was lost in cardiomyocytes isolated from 〖Adipo〗 DEGREES(-/-)mice but restored by recombinant APN, while this APN beneficial effect was abolished by either specific STAT3 or APN receptor1 (AdipoR1) gene knockdown, or caveolin-3 (Cav3) disruption. APN activated STAT3 and restored IPo cardioprotection in 4-week diabetic where AdipoR1 and Cav3 were functionally interactive, but not in 8-week diabetic rats whose cardiac Cav3 was severely reduced and AdipoR1/Cav3 signaling impaired. It is concluded that IPo activates mitoSTAT3 through APN/AdipoR1/Cav3 pathway to confer cardioprotection, while in diabetes, IPo loses cardioprotection due to impaired APN/AdipoR1/Cav3 signaling. It is hoped that studies described in this thesis have enhanced the knowledge concerning the role of APN in the cardioprotection of IPo against myocardial


Best Sellers


Product Details
  • ISBN-13: 9781361024577
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 194
  • Spine Width: 13 mm
  • Width: 216 mm
  • ISBN-10: 1361024577
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Language: English
  • Series Title: English
  • Weight: 744 gr


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)
Open Dissertation Press -
Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury in Type 1 Diabetes: (English)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA