The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Table of Contents:
I. Oxepins and Reduced Oxepins 1 A. Oxepins 1 B. Dihydrooxepins 14 C. Tetrahydrooxepins 26 D. Hexahydrooxepins (oxepans) 34 II. Oxepin Ring Systems Containing Two Rings 51 A. Fused rings systems 51 B. Spirans 102 C. Bridged systems 103 D. Tables 117 E. References 132 III. Oxepin Ring Systems Containing Three Rings 136 A. Fused ring systems 136 B. Bridged and spiran ring systems 227 C. Tables 233 D. References 253 IV. Oxepin Ring Systems Containing More Than Three Rings 259 A. Tetracyclic systems 259 B. Pentacyclic systems 290 C. Hexacyclic systems 301 D. Heptacyclic systems 306 E. Systems containing more than seven rings 312 F. References 316 V. Dioxepins and Trioxepins 319 A. Monocyclic dioxepins 319 B. Condensed dioxepins C. Trioxepins D. Tables 384 E. References 408 VI. Terpene Oxepins 412 A. Introduction 412 B. Ɛ -lactones and Ɛ-lactols 412 C. Anhydrides 437 D. Miscellaneous oxepins 439 E. Tables 447 F. References 462 VII. Steroidal Oxepins 467 A. Introduction 467 B. Nomenclature 467 C. Ring A oxepins 469 D. Ring B oxepins 497 E. Ring C oxepins 507 F. Tables 515 G. References 519 VIII. Oxepins Derived from Sugars 521 A. Introduction 521 B. Oxepins derived from hexoses 522 C. Oxepins derived from heptoses 543 D. Oxepins derived from sugars and aldehydes 553 E. Oxepins related to sugars 555 F. References 556 IX. Alkaloids Containing a Seven-Membered Oxygen Ring 560 A. Introduction 560 B. The strychnine group 561 D. Insularine and insulanoline 570 E. References 570 X. Monocyclic Seven-Membered Rings Containing Sulfur 573 A. Introduction 573 B. Rings containing one sulfur atom (thiepins and derivatives) 574 C. Rings containing two sulfur atoms (dithiepins and derivatives) 598 D. Rings containing three sulfur atoms (trithiepins and derivatives) 623 E. Rings containing four or more sulfur atoms (tetrathiepins,Pentathiepins, hexathiepins, s7, and derivatives) 634 F. Tables 646 G. References 661 XI. Condensed Thiepins 667 A. Introduction 667 B. 2H-cyclopenta[b]Thiepins 668 C. 1-benzo thiepins 668 D. 2-benzothiepins 709 E. 3-benzothiepins F. Naphthothiepins G. Dibenzo[b,d]thiepins 727 H. Dibenzo[b,e]thiepins 729 I. Dibenzo[b,f]thiepins 739 K. Benzonaphthothiepins 769 L. Tribenzo[b,d,f]thiepins 772 M. Thienothiepins and Benzothienothiepins 775 N. Furothiepins 782 0. Cycloalkadithiepins P. Benzodithiepins 787 Q. Dibenzodithiepins and Dinaphthodithiepins 790 R. Benzotrithiepins 791 S. Dinaphthotrithiepins 793 T. Benzopentathiepins 793 U. Physiological activity 794 V. Bridged systems W. Tables 811 X. References 887 Indexes