This monograph approaches from various angles the problematic difficulties of definition of multiple sclerosis. Although no figures or tables are included, a schematic series of attempts are made in terms of short review style the overall and specific highlights of pathologic involvement of the central nervous system in neurodegeneration, neuroinflammation and demyelination as seen in autopsy material. A clear concise style has been adopted that allows however the establishment of comprehensive inclusion of various pathogenic features of operative schematization of current understanding in MS pathogenesis. This volume is particularly suitable in view of the organic structuring of various operative factors in MS that interest students, post-graduates researchers of various disciplines, and also integrative information of interest to clinicians in active clinical investigations, and also pathologists and neuropathologists.

Table of Contents:
Preface; The Adaxonal Myelin Layer Triggers and Destabilizes Multiple Sclerosis Pathogenesis; Pathogenic Systems of Heterogeneity in Distinct Onset versus Progression Phases of Multiple Sclerosis in Terms of Amplifying Overlap of Immune Reactivities; Variability of Expressivity in Multiple Sclerosis Involves Pathogenic Diversity in Lesion Progression and in Attempted Lesion Reconstitution; Tightly Coupled Demyelination and Remyelination Constitute Basic Biology of Persistence in the Multiple Sclerosis Plaque in Terms of Neuronal/axonal Primal Injury Progression; The Essential Links between Genetic Susceptibility and Environmental Pathogens in Multiple Sclerosis Progression and Initiation; Performance Reactivation of Immune Response Defines Multiple Sclerosis Progression as Systems of Overlap Spread and Amplification via Endothelial Cells; A Multi-Factorial Genesis of the Multiple Sclerosis Triggering Event and of the Propagation of Progressing Lesions in the Central Nervous System; Attributes of Patterned Injury in Multiple Sclerosis Sequential Plaque Definitionthe Primal Vascular Wall Paradigm; Integral Biologic System-Induced Energy Failure Allows and Further Establishes Neurodegeneration and Inflammatory Demyelination in Multiple Sclerosis; Constitutive and Acquired Formulas of Transformation in Multiple Sclerosis; The Outcome of the Individual Multiple Sclerosis Plaque as Pre-Determined Parameter in Disease Progression or Potential Recovery; Elemental Context Definition in Integral Geography of Multiple Sclerosis Lesions; An Integral Formulation of Targeting Combinations of the Innate and Adaptive Immune Systems in Ms in Terms of Activated Vasculitis; Dimensions of Co-Operative Overlap of a Primal Autoimmunity of Contactual Repeated Antigenic Characterization in Multiple Sclerosis; Autoimmunity as Specific Enhanced Response to Cell Injury in Multiple Sclerosis Persistence and Re-Modulation in Terms of the Gut Microbiota Reconstitutive Profiles; Systems of Integrity as Interacting and Individual Subsystems in Multiple Sclerosis Networks in Terms of Cns Impaired Immune Privileged Status in Neuroinflammation; Instability of the Inflammasome Induces Eventual Autoimmunity in Multiple Sclerosis; Diversity in Injury Pathways Incorporated as Unitary Targeting Events in Multiple Sclerosis; An Essential Permissive Microenvironment as Primarily Passive Accumulation of Multiple Sclerosis Lesion Byproducts Redefines Disease Pathogenesis; Proposed Dynamics of Predetermination of Multiple Sclerosis Injury in Terms of Concurrent Potentiality for Recovery; Interface Interactivities as Systemic Biology Reconstitution in Multiple Sclerosis; Profiles of Transforming Activations of Immune Cells as Infiltrative Dimensions in Definition of T Cd4+ Helper Cells in Neuroinflammation of Multiple Sclerosis Type; Index.